The incidence of brain metastasis is rising and poses a severe clinical problem, as we lack
effective therapies and knowledge of mechanisms that control metastatic growth in the brain …

Systemic cytokine release and on-target/off-tumor toxicity to normal tissues are the main
adverse effects limiting the clinical utility of T cell–redirecting therapies. This study was …

Immunoconjugates and multispecific antibodies are rapidly emerging as highly potent
experimental therapeutics against cancer. We have developed a method to incorporate an …

Metastasis is the main cause of death in cancer patients, and understanding mechanisms
that control tumor cell dissemination may lead to improved therapy. Tumor cell adhesion …

Purpose: Poly (lactic-co-glycolic) acid (PLGA) inserts have been successfully developed for
the treatment of posterior eye disease as a means of reducing injection frequency of …

Current therapies for gliomas often fail to address their infiltrative nature. Conventional
treatments leave behind small clusters of neoplastic cells, resulting in eventual tumor …

We report a strategy for the generation of heterodimeric protein conjugates using an
unnatural amino acid with orthogonal reactivity. This paper addresses the challenges of site …

We have earlier shown that the rat neural progenitor cell line HiB5 is capable of suppressing
intracranial growth of glioma cells in Fisher rats. Unlike some neural progenitor cells, HiB5 …

Background Glioblastoma are highly aggressive tumors with an average survival time of 12
months with currently available treatment. We have previously shown that specific …

Immunomodulatory therapeutics such as monoclonal antibodies (mAb) carry an inherent risk
of undesired immune reactions. One such risk is cytokine release syndrome (CRS), a rapid …