Wnt signaling in ovarian tumorigenesis
TA Gatcliffe, BJ Monk, K Planutis… - International Journal of …, 2008 - ijgc.bmj.com
Data are emerging implicating Wnt signaling in ovarian tumorigenesis. We sought to review
the current literature on the subject and discuss the pathway's potential role as a prognostic …
the current literature on the subject and discuss the pathway's potential role as a prognostic …
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa …
…, MJ Stamos, MP Moyer, K Planutis… - Cancer management …, 2009 - Taylor & Francis
Context Resveratrol exhibits colon cancer prevention activity in animal models; it is
purported to have this activity in humans and inhibit a key signaling pathway involved in …
purported to have this activity in humans and inhibit a key signaling pathway involved in …
Role of canonical Wnt signaling in endometrial carcinogenesis
TH Dellinger, K Planutis, KS Tewari… - Expert review of …, 2012 - Taylor & Francis
While the role of Wnt signaling is well established in colorectal carcinogenesis, its function in
gynecologic cancers has not been elucidated. Here, we describe the current state of …
gynecologic cancers has not been elucidated. Here, we describe the current state of …
Expression of Wnt genes and frizzled 1 and 2 receptors in normal breast epithelium and infiltrating breast carcinoma
T Milovanovic, K Planutis… - International …, 2004 - spandidos-publications.com
The Wnt genes encode a family of related, secreted proteins which initiate a signal cascade
upon binding to cell surface receptor molecules. The signaling pathway has been shown to …
upon binding to cell surface receptor molecules. The signaling pathway has been shown to …
Low concentrations of resveratrol inhibit Wnt signal throughput in colon‐derived cells: implications for colon cancer prevention
C Hope, K Planutis, M Planutiene… - Molecular nutrition & …, 2008 - Wiley Online Library
Resveratrol is a bioflavonoid which is known to inhibit cell proliferation and induce apoptosis
in cancer cell lines at concentrations above 50 μM. It also has colon cancer prevention …
in cancer cell lines at concentrations above 50 μM. It also has colon cancer prevention …
Wnt pathway component LEF1 mediates tumor cell invasion and is expressed in human and murine breast cancers lacking ErbB2 (her-2/neu) overexpression
…, T Milovanovic, C Hope, K Planutis… - International …, 2005 - spandidos-publications.com
This study examines the role of LEF1, a component of the Wnt signaling pathway, in human
breast and murine mammary carcinoma and its relationship to ErbB2 (her-2/neu) …
breast and murine mammary carcinoma and its relationship to ErbB2 (her-2/neu) …
[HTML][HTML] Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human …
M Planutiene, K Planutis, RF Holcombe - Vascular cell, 2011 - Springer
Background Wnt signaling is activated in many types of cancer and normal physiological
processes. Various Wnt-related secreted factors may influence angiogenesis both in the …
processes. Various Wnt-related secreted factors may influence angiogenesis both in the …
[HTML][HTML] Invasive colon cancer, but not non-invasive adenomas induce a gradient effect of Wnt pathway receptor frizzled 1 (Fz1) expression in the tumor …
K Planutis, M Planutiene, AV Nguyen… - Journal of Translational …, 2013 - Springer
Background Wnt signaling in the colon cancer tumor microenvironment (TME) may affect
cancer biologic properties including invasion and metastatic dissemination. Prior reports …
cancer biologic properties including invasion and metastatic dissemination. Prior reports …
Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial …
TH Dellinger, K Planutis, DD Jandial, RN Eskander… - Gynecologic …, 2012 - Elsevier
OBJECTIVE: Emerging evidence implicates the Wnt antagonist Dickkopf-3 (Dkk3) as a tumor
suppressor and potential biomarker in solid tumors. We investigated whether Dkk3 plays an …
suppressor and potential biomarker in solid tumors. We investigated whether Dkk3 plays an …
[HTML][HTML] A novel signaling pathway regulates colon cancer angiogenesis through Norrin
K Planutis, M Planutiene, RF Holcombe - Scientific reports, 2014 - nature.com
Norrin binds to the frizzled-4 receptor, stimulating canonical Wnt signaling. We investigate
here the role of colorectal cancer (CRC) produced Norrin in endothelial cell growth, motility …
here the role of colorectal cancer (CRC) produced Norrin in endothelial cell growth, motility …