User profiles for "author:K. Kurose"

Koji Kurose

Department of respiratory medicine Kawasaki Medical School
Verified email at med.kawasaki-m.ac.jp
Cited by 542

Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in …

K Kurose, E Sugiyama, Y Saito - Drug metabolism and …, 2012 - jstage.jst.go.jp
Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

K Kurose, K Gilley, S Matsumoto, PH Watson… - Nature …, 2002 - nature.com
We have recently shown that loss of heterozygosity of specific markers, including those at
10q23, 17p13–p15 and 16q24, can occur in the stromal and epithelial compartments of …

HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis

…, Y Saito, M Aihara, K Matsunaga, M Tohkin, K Kurose… - 2008 - Future Medicine
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations …

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian …

K Kurose, XP Zhou, T Araki, SA Cannistra… - The American journal of …, 2001 - Elsevier
PTEN (MMAC1/TEP1), a tumor suppressor gene on chromosome subband 10q23. 3, is
variably mutated and/or deleted in a variety of human cancers. Germline mutations in PTEN …

HLA‐B*1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients

…, M Aihara, K Matsunaga, M Tohkin, K Kurose… - …, 2010 - Wiley Online Library
Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life‐
threatening severe cutaneous adverse reactions. Recently, strong associations of HLA‐B …

Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population

…, K Shiseki, M Saeki, T Nakamura, K Kurose… - Human …, 2004 - Wiley Online Library
In order to identify single nucleotide polymorphisms (SNPs) and haplotype frequencies of
CYP3A4 in a Japanese population, the distal enhancer and proximal promoter regions, all …

[PDF][PDF] Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

…, K Woodford-Richens, R Lehtonen, K Kurose… - The American Journal of …, 2001 - cell.com
Juvenile polyposis syndrome (JPS) is an inherited hamartomatous-polyposis syndrome with
a risk for colon cancer. JPS is a clinical diagnosis by exclusion, and, before susceptibility …

A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients

…, N Kaniwa, Y Saito, E Sugiyama, K Kurose… - The …, 2013 - nature.com
Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe,
cutaneous adverse drug reactions that are rare but life threatening. Genetic biomarkers for …

Arylhydrocarbon receptor-dependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated …

…, E Azuma, T Nakajima, M Shindo, K Kurose… - …, 2002 - academic.oup.com
Arylhydrocarbon receptor knock-out, AhR (–/–), mice have recently been shown to be rather
resistant to benzo [a] pyrene (B [a] P)-induced tumor formation, probably reflecting the …

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

K Kurose, Y Ohue, H Wada, S Iida, T Ishida… - Clinical Cancer …, 2015 - AACR
Abstract Purpose: FoxP3+ Tregs inhibit immune responses against tumors. KW-0761 is a
humanized anti-human CCR4 monoclonal antibody (mAb) that has antibody-dependent …