The landscape of genetic testing in ovarian cancer patients has changed dramatically in
recent years. The therapeutic benefits of poly ADP-ribose polymerase (PARP) inhibitors in …

Next-generation sequencing (NGS) technologies have facilitated multi-gene panel (MGP)
testing to detect germline DNA variants in hereditary cancer patients. This sensitive …

Tobacco smoke is an established carcinogen, but the association between tobacco smoking
and cancer risk in BRCA mutation carriers is not clear. The aim of this study was to evaluate …

Purpose There are established differences in breast cancer epidemiology between Asian
and white individuals, but little is known about hereditary breast cancer in Asian populations …

Abstract Background BRCA1 and BRCA2 (BRCA) mutation carriers face a high lifetime risk
of developing ovarian cancer. Oral contraceptives are protective in this population; however …

Background Approximately 14% of British Colum bians live in rural and remote regions and
have limited access to health services, including genetic counseling for hereditary cancer …

Objective In 2001, the province of Ontario expanded cancer genetic testing eligibility to
include all women with high-grade serous ovarian carcinoma (HGSC) of the ovary, fallopian …

Methods A multidisciplinary steering committee guided the process of an environmental
scan to define the current landscape, as well as the perceived challenges, through …

As demand for genetic counseling regarding hereditary cancer continues to grow, more
efficient methods of providing this service must be explored. In this pilot study, group genetic …

Purpose. In order to meet a clinical need for better pathways to access genetic testing for
ovarian cancer patients, we implemented and reviewed an opt-out referral process for …