[HTML][HTML] Notch signaling in serous ovarian cancer
JW Groeneweg, R Foster, WB Growdon… - Journal of ovarian …, 2014 - Springer
Ovarian cancer is the most lethal of all gynecologic malignancies because women
commonly present with advanced stage disease and develop chemotherapy refractory …
commonly present with advanced stage disease and develop chemotherapy refractory …
[HTML][HTML] Response to systemic therapies in ovarian adult granulosa cell tumors: a literature review
GJ Brink, JW Groeneweg, L Hooft, RP Zweemer… - Cancers, 2022 - mdpi.com
Simple Summary Adult granulosa cell tumors (aGCTs) are a rare subtype of ovarian cancer.
First choice of treatment is surgery; when this is not possible, chemotherapy and anti …
First choice of treatment is surgery; when this is not possible, chemotherapy and anti …
[HTML][HTML] Whole genome analysis of ovarian granulosa cell tumors reveals tumor heterogeneity and a high-grade TP53-specific subgroup
J Roze, G Monroe, J Kutzera, J Groeneweg, E Stelloo… - Cancers, 2020 - mdpi.com
Adult granulosa cell tumors (AGCTs) harbor a somatic FOXL2 c. 402C> G mutation in~ 95%
of cases and are mainly surgically removed due to limited systemic treatment effect. In this …
of cases and are mainly surgically removed due to limited systemic treatment effect. In this …
[HTML][HTML] HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant
WB Growdon, J Groeneweg, V Byron, C DiGloria… - Gynecologic …, 2015 - Elsevier
Background Subsets of high grade endometrial cancer (EnCa) over-express HER2
(ERBB2), yet clinical trials have failed to demonstrate any anti-tumor activity utilizing …
(ERBB2), yet clinical trials have failed to demonstrate any anti-tumor activity utilizing …
[HTML][HTML] Inhibition of notch signaling in combination with Paclitaxel reduces platinum-resistant ovarian tumor growth
JW Groeneweg, CM DiGloria, J Yuan… - Frontiers in …, 2014 - frontiersin.org
Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United
States because of chemoresistant recurrent disease. Our objective was to investigate the …
States because of chemoresistant recurrent disease. Our objective was to investigate the …
[HTML][HTML] FOXL2 and TERT promoter mutation detection in circulating tumor DNA of adult granulosa cell tumors as biomarker for disease monitoring
JW Groeneweg, JF Roze, EDJ Peters, F Sereno… - Gynecologic …, 2021 - Elsevier
Objective Adult granulosa cell tumors (aGCTs) represent a rare, hormonally active subtype
of ovarian cancer that has a tendency to relapse late and repeatedly. Current serum …
of ovarian cancer that has a tendency to relapse late and repeatedly. Current serum …
Assessing the efficacy of targeting the phosphatidylinositol 3-kinase/AKT/mTOR signaling pathway in endometrial cancer
LS Bradford, A Rauh-Hain, RM Clark… - Gynecologic …, 2014 - Elsevier
Objective Alterations in the PI3K pathway are prevalent in endometrial cancer due to
PIK3CA mutation and loss of PTEN. We investigated the anti-tumor activity of the PI3K …
PIK3CA mutation and loss of PTEN. We investigated the anti-tumor activity of the PI3K …
Dual HER2 Targeting Impedes Growth of HER2 Gene–Amplified Uterine Serous Carcinoma Xenografts
JW Groeneweg, SF Hernandez, VF Byron… - Clinical Cancer …, 2014 - AACR
Purpose: Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer
that commonly harbors HER2 gene amplification. We investigated the effectiveness of HER2 …
that commonly harbors HER2 gene amplification. We investigated the effectiveness of HER2 …
[HTML][HTML] In vitro systematic drug testing reveals carboplatin, paclitaxel, and alpelisib as a potential novel combination treatment for adult granulosa cell tumors
J Roze, E Sendino Garví, E Stelloo, C Stangl, F Sereno… - Cancers, 2021 - mdpi.com
Simple Summary Granulosa cell tumor treatment is challenging as there are few effective
options besides surgery. In this study, we obtained tumor tissue from patients at surgery and …
options besides surgery. In this study, we obtained tumor tissue from patients at surgery and …
Inhibition of gamma-secretase activity impedes uterine serous carcinoma growth in a human xenograft model
JW Groeneweg, TR Hall, L Zhang, M Kim, VF Byron… - Gynecologic …, 2014 - Elsevier
Objective Uterine serous carcinoma (USC) represents an aggressive subtype of endometrial
cancer. We sought to understand Notch pathway activity in USC and determine if pathway …
cancer. We sought to understand Notch pathway activity in USC and determine if pathway …