We examine trends in racial and ethnic discrimination in US housing and mortgage lending
markets through a quantitative review of studies. We code and analyze as a time series …

After two rather brief chapters dealing with collection and preparatory techniques and
ecology, both almost exclusively concerned with free-living organisms, this book consists of …

Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are
responsible for the patterning of a variety of embryonic structures in vertebrates and …

THE secreted protein products of the hedgehog (hh) gene family are associated with local
and long-range signalling activities that are responsible for developmental patterning in …

The segment polarity genes engrailed and wingless are expressed in neighboring stripes of
cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually …

In a screen of drugs previously tested in humans we identified itraconazole, a systemic
antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a …

Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human
malignancies, with no truly effective therapies for advanced disease. Preclinical studies …

The mutated gene responsible for the tubby obesity phenotype has been identified by
positional cloning. A single base change within a splice donor site results in the incorrect …

Aberrant Hedgehog (Hh) pathway activation has been implicated in cancers of diverse
tissues and organs, and the tumor growth-inhibiting effects of pathway antagonists in animal …

BACKGROUND & AIMS: Paneth cells contribute to the small intestinal niche of Lgr5+ stem
cells. Although the colon also contains Lgr5+ stem cells, it does not contain Paneth cells. We …