Introduction and hypothesis Pelvic organ prolapse (POP) is a common condition with
multifactorial etiology. The purpose of this systematic review was to provide an overview of …

In research aimed at improving human health care, animal studies still play a crucial role,
despite political and scientific efforts to reduce preclinical experimentation in laboratory …

Objective To update a previously published systematic review and perform a meta-analysis
on the risk factors for primary pelvic organ prolapse and prolapse recurrence. Data Sources …

Abstract Background The DerSimonian and Laird approach (DL) is widely used for random
effects meta-analysis, but this often results in inappropriate type I error rates. The method …

Objectives Evaluating the variation in the strength of the effect across studies is a key feature
of meta-analyses. This variability is reflected by measures like τ2 or I2, but their clinical …

Objectives Between-study heterogeneity plays an important role in random-effects models
for meta-analysis. Most clinical trials are small, and small trials are often associated with …

Objective To investigate whether uterus preserving vaginal sacrospinous hysteropexy is non-
inferior to vaginal hysterectomy with suspension of the uterosacral ligaments in the surgical …

Meta-analyses are increasingly used for synthesis of evidence from biomedical research,
and often include an assessment of publication bias based on visual or analytical detection …

Background. Immunization of healthy volunteers by bites from Plasmodium falciparum–
infected mosquitoes during chloroquine chemoprophylaxis (hereafter, chemoprophylaxis …

Context Urethra repair by tissue engineering has been extensively studied in laboratory
animals and patients, but is not routinely used in clinical practice. Objective To …