Hypoxic tissue conditions occur during a number of inflammatory diseases and are
associated with the breakdown of barriers and induction of proinflammatory responses. At …

CD73, a cell surface 5′ nucleotidase that generates adenosine, has emerged as an
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …

January 2018• Volume 126• Number 1 www. anesthesia-analgesia. org 309 targeted
therapeutically in patients as a potential treatment approach for the prevention or treatment …

Ecto-5′-nucleotidase (CD73) is central to the generation of extracellular adenosine.
Previous studies have highlighted a detrimental role for extracellular adenosine in cancer …

Intestinal epithelial barrier repair is vital for remission in inflammatory bowel disease (IBD).
Extracellular adenosine signaling has been implicated in promoting restoration of epithelial …

Of the total human body's surface, the majority is internal surface, belonging to the lungs
(100 m 2) and intestinal tract (400 m 2). In comparison, the external surface area, belonging …

Intestinal inflammation is a key element in inflammatory bowel disease and is related to a
combination of factors, including genetics, mucosal barrier dysfunction, bacteria …

Background During myocardial ischemia, hypoxia-inducible factors are stabilized and
provide protection from ischemia and reperfusion injury. Recent studies show that myocyte …

Loss of terminal cell differentiation promotes tumorigenesis. 15-Lipoxygenase-1 (15-LOX-1)
contributes to terminal cell differentiation in normal cells. The mechanistic significance of 15 …

Purinergic signaling is a fundamental mechanism used by all cells to control their internal
activities and interact with the environment. A key component of the purinergic system, the …