Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer
DN Church, E Stelloo, RA Nout… - Journal of the …, 2015 - academic.oup.com
Background: Current risk stratification in endometrial cancer (EC) results in frequent over-
and underuse of adjuvant therapy, and may be improved by novel biomarkers. We …
and underuse of adjuvant therapy, and may be improved by novel biomarkers. We …
[HTML][HTML] Identification of nine new susceptibility loci for endometrial cancer
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …
in developed countries. Through genome-wide association studies (GWAS), we have …
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape …
D Temko, IC Van Gool, E Rayner… - The Journal of …, 2018 - Wiley Online Library
Genomic instability, which is a hallmark of cancer, is generally thought to occur in the middle
to late stages of tumourigenesis, following the acquisition of permissive molecular …
to late stages of tumourigenesis, following the acquisition of permissive molecular …
Five endometrial cancer risk loci identified through genome-wide association analysis
We conducted a meta-analysis of three endometrial cancer genome-wide association
studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and …
studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and …
Genetic risk score Mendelian randomization shows that obesity measured as body mass index, but not waist: hip ratio, is causal for endometrial cancer
Background: The strongest known risk factor for endometrial cancer is obesity. To determine
whether SNPs associated with increased body mass index (BMI) or waist–hip ratio (WHR) …
whether SNPs associated with increased body mass index (BMI) or waist–hip ratio (WHR) …
Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways
T Cuppens, M Moisse, J Depreeuw… - … journal of cancer, 2018 - Wiley Online Library
Uterine leiomyosarcomas (uLMS) are rare, aggressive malignancies for which limited
treatment options are available. To gain novel molecular insights into uLMS and identify …
treatment options are available. To gain novel molecular insights into uLMS and identify …
Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
Epidemiological, biological, and molecular data suggest links between endometriosis and
endometrial cancer, with recent epidemiological studies providing evidence for an …
endometrial cancer, with recent epidemiological studies providing evidence for an …
[HTML][HTML] CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
Established risk factors for endometrial cancer include high BMI (IARC 2002), early
menarche, late menopause, nulliparity, estrogen-only hormone replacement therapy …
menarche, late menopause, nulliparity, estrogen-only hormone replacement therapy …
[HTML][HTML] Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy
Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have
been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of …
been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of …
Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies
J Depreeuw, E Hermans, S Schrauwen, D Annibali… - Gynecologic …, 2015 - Elsevier
Objective Endometrial carcinoma (EC) is the sixth most common cancer in women and
therapies are limited for advanced and recurrent disease. Patient-derived tumor xenograft …
therapies are limited for advanced and recurrent disease. Patient-derived tumor xenograft …