ras Oncogenes in Human Cancer: A Review
JL Bos - Cancer research, 1989 - AACR
Abstract Mutations in codon 12, 13, or 61 of one of the three ras genes, H-ras, K-ras, and N-
ras, convert these genes into active oncogenes. Rapid assays for the detection of these …
ras, convert these genes into active oncogenes. Rapid assays for the detection of these …
[HTML][HTML] GEFs and GAPs: critical elements in the control of small G proteins
JL Bos, H Rehmann, A Wittinghofer - Cell, 2007 - cell.com
Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs)
regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular …
regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular …
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction …
…, KK Bose, JL Cameron, JL Bos - The American journal …, 1993 - ncbi.nlm.nih.gov
We examined 82 surgically resected or biopsied, formalin-fixed, paraffin-embedded primary
adenocarcinomas of the pancreas for the presence of activating point mutations in codon 12 …
adenocarcinomas of the pancreas for the presence of activating point mutations in codon 12 …
Genetic alterations during colorectal-tumor development
…, M Leppert, AMM Smits, JL Bos - … England Journal of …, 1988 - Mass Medical Soc
Because most colorectal carcinomas appear to arise from adenomas, studies of different
stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor …
stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor …
Prevalence of ras gene mutations in human colorectal cancers
JL Bos, ER Fearon, SR Hamilton, MV Vries… - Nature, 1987 - nature.com
Abstract The Department of Medical Biochemistry and t Department of Organic Chemistry,
State University of Leiden, Sylvius Laboratories, The Netherlands* The Oncology Center …
State University of Leiden, Sylvius Laboratories, The Netherlands* The Oncology Center …
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
Rap1 is a small, Ras-like GTPase that was first identified as a protein that could suppress
the oncogenic transformation of cells by Ras. Rap1 is activated by several extracellular …
the oncogenic transformation of cells by Ras. Rap1 is activated by several extracellular …
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
The Forkhead transcription factors AFX, FKHR and FKHR-L1 are orthologues of DAF-16, a
Forkhead factor that regulates longevity in Caenorhabditis elegans,,. Here we show that …
Forkhead factor that regulates longevity in Caenorhabditis elegans,,. Here we show that …
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Reactive oxygen species are required for cell proliferation but can also induce apoptosis. In
proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also …
proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also …
Direct control of the Forkhead transcription factor AFX by protein kinase B
Abstract The phosphatidylinositol-3-OH-kinase (PI (3) K) effector protein kinase B (,)
regulates certain insulin-responsive genes,, but the transcription factors regulated by protein …
regulates certain insulin-responsive genes,, but the transcription factors regulated by protein …
[PDF][PDF] Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
Tumor suppressor genes evolved as negative effectors of mitogen and nutrient signaling
pathways, such that mutations in these genes can lead to pathological states of growth …
pathways, such that mutations in these genes can lead to pathological states of growth …