Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer
WD Foulkes, IM Stefansson… - Journal of the …, 2003 - academic.oup.com
A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers.
Microarray studies have shown that this phenotype is associated with breast cancers that …
Microarray studies have shown that this phenotype is associated with breast cancers that …
[PDF][PDF] EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate …
IM Bachmann, OJ Halvorsen, K Collett, IM Stefansson… - J Clin Oncol, 2006 - academia.edu
Purpose EZH2 is a member of the polycomb group of genes and important in cell cycle
regulation. Increased expression of EZH2 has been associated previously with invasive …
regulation. Increased expression of EZH2 has been associated previously with invasive …
The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1-Related Breast Cancer
WD Foulkes, JS Brunet, IM Stefansson, O Straume… - Cancer research, 2004 - AACR
Previous studies have shown that BRCA1-related breast cancers are often high-grade
tumors that do not express estrogen receptors, HER2, p27Kip1, or cyclin D1, but do express …
tumors that do not express estrogen receptors, HER2, p27Kip1, or cyclin D1, but do express …
Drug-sensitive FGFR2 mutations in endometrial carcinoma
A Dutt, HB Salvesen, TH Chen… - Proceedings of the …, 2008 - National Acad Sciences
Oncogenic activation of tyrosine kinases is a common mechanism of carcinogenesis and,
given the druggable nature of these enzymes, an attractive target for anticancer therapy …
given the druggable nature of these enzymes, an attractive target for anticancer therapy …
Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer.
K Collett, GE Eide, J Arnes, IM Stefansson, J Eide… - Clinical cancer research …, 2006 - AACR
The polycomb group protein enhancer of zeste homologue 2 (EZH2) has been linked to
invasive properties of aggressive breast cancer. In this report, tissue microarray analysis of …
invasive properties of aggressive breast cancer. In this report, tissue microarray analysis of …
A basal epithelial phenotype is more frequent in interval breast cancers compared with screen detected tumors
K Collett, IM Stefansson, J Eide, A Braaten… - … Biomarkers & Prevention, 2005 - AACR
Interval breast cancer reduce the effectiveness of mammography screening programs. We
studied 95 interval cancers, diagnosed during 1996 to 2001 as part of the population-based …
studied 95 interval cancers, diagnosed during 1996 to 2001 as part of the population-based …
The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis
Recent studies have detailed the genomic landscape of primary endometrial cancers, but
the evolution of these cancers into metastases has not been characterized. We performed …
the evolution of these cancers into metastases has not been characterized. We performed …
[HTML][HTML] Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses
G Bredholt, M Mannelqvist, IM Stefansson… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Aims Tumor necrosis is associated with aggressive features of endometrial cancer and poor
prognosis. Here, we investigated gene expression patterns and potential treatment targets …
prognosis. Here, we investigated gene expression patterns and potential treatment targets …
Lack of estrogen receptor-α is associated with epithelial–mesenchymal transition and PI3K alterations in endometrial carcinoma
E Wik, MB Ræder, C Krakstad, J Trovik… - Clinical Cancer …, 2013 - AACR
Purpose: We hypothesized that estrogen receptor-α (ER-α) status in endometrial
carcinomas, associated with poor prognosis, is reflected in transcriptional signatures …
carcinomas, associated with poor prognosis, is reflected in transcriptional signatures …
[HTML][HTML] Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial
J Trovik, E Wik, HMJ Werner, C Krakstad… - European journal of …, 2013 - Elsevier
Background Preoperative histologic examination of tumour tissue is essential when deciding
if endometrial cancer surgery should include lymph node sampling. We wanted to …
if endometrial cancer surgery should include lymph node sampling. We wanted to …