[HTML][HTML] Tryptophan metabolism in inflammaging: from biomarker to therapeutic target

FJH Sorgdrager, PJW Naudé, IP Kema… - Frontiers in …, 2019 - frontiersin.org
Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline
of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype …

Clinical chemistry of serotonin and metabolites

IP Kema, EGE de Vries, FAJ Muskiet - Journal of Chromatography B …, 2000 - Elsevier
Analyses of serotonin and other 5-hydroxyindoles, such as its precursor 5-
hydroxytryptophan and major metabolite 5-hydroxyindoleacetic acid (5-HIAA), are …

Molecular imaging in neuroendocrine tumors: molecular uptake mechanisms and clinical results

KP Koopmans, ON Neels, IP Kema, PH Elsinga… - Critical reviews in …, 2009 - Elsevier
Neuroendocrine tumors can originate almost everywhere in the body and consist of a great
variety of subtypes. This paper focuses on molecular imaging methods using nuclear …

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

JC Chambers, W Zhang, J Sehmi, X Li, MN Wass… - Nature …, 2011 - nature.com
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We
carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

A Vrieze, C Out, S Fuentes, L Jonker, I Reuling… - Journal of …, 2014 - Elsevier
Background & Aims Obesity has been associated with changes in the composition and
function of the intestinal microbiota. Modulation of the microbiota by antibiotics also alters …

Seventy-five genetic loci influencing the human red blood cell

P Van Der Harst, W Zhang, I Mateo Leach, A Rendon… - Nature, 2012 - nature.com
Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

Accuracy of 6 routine 25-hydroxyvitamin D assays: influence of vitamin D binding protein concentration

AC Heijboer, MA Blankenstein, IP Kema… - Clinical …, 2012 - academic.oup.com
BACKGROUND Recent recognition of its broad pathophysiological importance has
triggered an increased interest in 25-hydroxyvitamin D [25 (OH) D]. By consequence …

Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l

MF Luxwolda, RS Kuipers, IP Kema… - British Journal of …, 2012 - cambridge.org
Cutaneous synthesis of vitamin D by exposure to UVB is the principal source of vitamin D in
the human body. Our current clothing habits and reduced time spent outdoors put us at risk …

Staging of carcinoid tumours with 18F-DOPA PET: a prospective, diagnostic accuracy study

KP Koopmans, EGE de Vries, IP Kema… - The lancet …, 2006 - thelancet.com
Background To assess individual treatment options for patients with carcinoid tumours,
accurate knowledge of tumour localisation is essential. We aimed to test the diagnostic …

[PDF][PDF] Improved staging of patients with carcinoid and islet cell tumors with 18F-dihydroxy-phenyl-alanine and 11C-5-hydroxy-tryptophan positron emission …

KP Koopmans, OC Neels, IP Kema… - Journal of clinical …, 2008 - researchgate.net
Improved Staging of Patients With Carcinoid and Islet Cell Tumors With 18F-Dihydroxy-Phenyl-Alanine
and 11C-5-Hydroxy-Tryptophan Page 1 Improved Staging of Patients With Carcinoid and Islet …