Bile acid synthesis is a major pathway for cholesterol disposal and thus represents a
potential therapeutic target pathway for the treatment of hypercholesterolemia. Recently, the …

Exercise benefits a variety of organ systems in mammals, and some of the best-recognized
effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co …

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against
hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat …

Bile acids are essential for the solubilization and transport of dietary lipids and are the major
products of cholesterol catabolism. Results presented here show that bile acids are …

The discovery of oxysterols as the endogenous liver X receptor (LXR) ligands and
subsequent gene targeting studies in mice provided strong evidence that LXR plays a …

Sterol regulatory element-binding protein-1c (SREBP-1c) enhances transcription of genes
encoding enzymes of unsaturated fatty acid biosynthesis in liver. SREBP-1c mRNA is known …

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects
of physical activity. In particular, irisin has been shown to have beneficial effects in adipose …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

Objective The aim of this article was to investigate the survival impact of ovarian
preservation in surgically treated patients with early-stage endometrial cancer using a meta …

Chemokine (CC motif) receptor-like 2 (CCRL2) binds leukocyte chemoattractant chemerin
and can regulate local levels of the attractant, but does not itself support cell migration. In …