Milestones of Lynch syndrome: 1895–2015
HT Lynch, CL Snyder, TG Shaw, CD Heinen… - Nature Reviews …, 2015 - nature.com
Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
condition, is characterized by the predisposition to a spectrum of cancers, primarily …
[HTML][HTML] Hereditary colorectal cancer
HT Lynch, A De la Chapelle - New England Journal of Medicine, 2003 - Mass Medical Soc
Colorectal cancers among patients with a familial risk of this disorder account for
approximately one of five cases of this disease. Many cases can be prevented by the …
approximately one of five cases of this disease. Many cases can be prevented by the …
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications
HT Lynch, PM Lynch, SJ Lanspa, CL Snyder… - Clinical …, 2009 - Wiley Online Library
More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
conservatively, approximately 3%(∼ 30,700 cases) will have Lynch syndrome (LS), the most …
Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …
common autosomal dominant syndrome characterized by early age at onset, neoplastic …
[HTML][HTML] Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
FS Leach, NC Nicolaides, N Papadopoulos, B Liu… - Cell, 1993 - cell.com
Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …
cancer (HNPCC) is on chromosome 2p and that tumors developing in these patients contain …
[HTML][HTML] Prophylactic Oophorectomy in Carriers of BRCA1 or BRCA2 Mutations
TR Rebbeck, HT Lynch, SL Neuhausen… - … England Journal of …, 2002 - Mass Medical Soc
Background Data concerning the efficacy of bilateral prophylactic oophorectomy for
reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are …
reducing the risk of gynecologic cancer in women with BRCA1 or BRCA2 mutations are …
Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality
Context Mastectomy and salpingo-oophorectomy are widely used by carriers of BRCA1 or
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …
BRCA2 mutations to reduce their risks of breast and ovarian cancer. Objective To estimate …
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC
HFA Vasen, P Watson, JP Mecklin, HT Lynch - Gastroenterology, 1999 - Elsevier
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome)
proposed by the International Collaborative Group on HNPCC - ScienceDirect Skip to main …
proposed by the International Collaborative Group on HNPCC - ScienceDirect Skip to main …
[PDF][PDF] Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
TR Rebbeck, T Friebel, HT Lynch… - Journal of clinical …, 2004 - seom.org
Purpose Data on the efficacy of bilateral prophylactic mastectomy for breast cancer risk
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …
reduction in women with BRCA1 and BRCA2 (BRCA1/2) mutations are limited, despite the …
Mutation of a mutL Homolog in Hereditary Colon Cancer
N Papadopoulos, NC Nicolaides, YF Wei, SM Ruben… - Science, 1994 - science.org
Some cases of hereditary nonpolyposis colorectal cancer (HNPCC) are due to alterations in
a mutS-related mismatch repair gene. A search of a large database of expressed sequence …
a mutS-related mismatch repair gene. A search of a large database of expressed sequence …