[HTML][HTML] Apoptosis and molecular targeting therapy in cancer
M Hassan, H Watari, A AbuAlmaaty, Y Ohba… - BioMed research …, 2014 - hindawi.com
Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …
[HTML][HTML] Tumor-intrinsic PD-L1 signaling in cancer initiation, development and treatment: beyond immune evasion
P Dong, Y Xiong, J Yue, SJB Hanley, H Watari - Frontiers in oncology, 2018 - frontiersin.org
Although the role of PD-L1 in suppressing the anti-tumor immune response is extensively
documented, recent discoveries indicate a distinct tumor-intrinsic role for PD-L1 in …
documented, recent discoveries indicate a distinct tumor-intrinsic role for PD-L1 in …
[HTML][HTML] Long non-coding RNA NEAT1: a novel target for diagnosis and therapy in human tumors
…, SJB Hanley, N Kobayashi, Y Todo, H Watari - Frontiers in …, 2018 - frontiersin.org
The nuclear paraspeckle assembly transcript 1 (NEAT1, a long non-coding RNA) is
frequently overexpressed in human tumors, and higher NEAT1 expression is correlated with …
frequently overexpressed in human tumors, and higher NEAT1 expression is correlated with …
Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind …
…, T Saito, K Takehara, T Enomoto, H Watari… - The lancet …, 2017 - thelancet.com
Background Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously
shown efficacy in a phase 2 study when given in capsule formulation to all-comer patients …
shown efficacy in a phase 2 study when given in capsule formulation to all-comer patients …
Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis
Y Todo, H Kato, M Kaneuchi, H Watari, M Takeda… - The Lancet, 2010 - thelancet.com
Background In response to findings that pelvic lymphadenectomy does not have any
therapeutic benefit for endometrial cancer, we aimed to establish whether complete …
therapeutic benefit for endometrial cancer, we aimed to establish whether complete …
Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis …
…, T Saito, K Takehara, T Enomoto, H Watari… - The Lancet …, 2021 - thelancet.com
Background Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously
been shown to extend progression-free survival versus placebo when given to patients with …
been shown to extend progression-free survival versus placebo when given to patients with …
[HTML][HTML] Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
…, M Karaayvaz, N Jia, M Kaneuchi, J Hamada, H Watari… - Oncogene, 2013 - nature.com
The tumor suppressor gene p53 has been implicated in the regulation of epithelial–
mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) …
mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) …
[HTML][HTML] Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity
…, SR King, Y Du, CB Kallen, LP Walsh, H Watari… - Journal of Biological …, 1997 - ASBMB
Steroidogenic acute regulatory protein (StAR) plays a critical role in steroid hormone
synthesis. StAR is thought to increase the delivery of cholesterol to the inner mitochondrial …
synthesis. StAR is thought to increase the delivery of cholesterol to the inner mitochondrial …
[HTML][HTML] Nivolumab versus gemcitabine or pegylated liposomal doxorubicin for patients with platinum-resistant ovarian cancer: open-label, randomized trial in Japan …
…, M Mandai, H Nakai, N Sakuragi, H Watari… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
PURPOSE This phase III, multicenter, randomized, open-label study investigated the
efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated …
efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated …
[HTML][HTML] MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
P Dong, M Kaneuchi, H Watari, J Hamada, S Sudo… - Molecular cancer, 2011 - Springer
Background Epithelial-mesenchymal transition (EMT) is the key process driving cancer
metastasis. Oncogene/self renewal factor BMI-1 has been shown to induce EMT in cancer …
metastasis. Oncogene/self renewal factor BMI-1 has been shown to induce EMT in cancer …