Clear cell carcinoma (CCC) accounts for 4% to 12% of epithelial ovarian cancer in Western
countries and, for some unknown reasons, it comprises more than 20% of such cancers in …

Nedaplatin, a cisplatin analog, has been developed to decrease the toxicities induced by
cisplatin, such as nephrotoxicity and gastrointestinal toxicity. The dose of nedaplatin is …

Clear cell carcinoma of the ovary (CCC) is a histologic subtype of epithelial ovarian cancer
with a distinct clinical behavior. There are marked geographic differences in the prevalence …

MicroRNAs (miRNAs) are small noncoding RNAs that direct gene regulation through
translational repression and degradation of complementary mRNA. Although miRNAs have …

Purpose: High-grade serous ovarian cancers are heterogeneous not only in terms of clinical
outcome but also at the molecular level. Our aim was to establish a novel risk classification …

Cancer cells acquire pathological phenotypes through accumulation of mutations that
perturb signaling networks. However, global analysis of these events is currently limited …

The tumor suppressor PTEN acts as a lipid phosphatase, regulates the phosphatidylinositol
3-kinase (PI3K)/Akt-signaling pathway, and modulates cell cycle progression and cell …

OBJECTIVE To estimate whether and how the biologic behavior of clear cell carcinoma
contributes to the chemoresistance mechanism. METHODS Forty-one patients with clear cell …

Aims: The aim of the present study was to evaluate the outcome of patients with stage Ib-IIb
cervical adenocarcinoma treated with radical hysterectomy, and to determine the …

Background: Ovarian clear cell carcinoma (OCCC) is mostly resistant to standard
chemotherapy that results in poor patient survival. To understand the genetic background of …