Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Because of their large surface area and immunological competence, mucosal tissues are
attractive administration and target sites for vaccination. An important characteristic of …

Over the past decade, major leaps forward have been made on the mechanistic
understanding and identification of adaptive stress response landscapes underlying toxic …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage.
Experimental in vitro models that faithfully capture the hallmarks and tumor heterogeneity of …

Several dominant mutations of the mouse agouti coat colour gene have pleiotropic effects
that include obesity and a yellow coat. The A y allele is caused by a large deletion that …

The mouse agouti gene controls the deposition of yellow and black pigment in developing
hairs. Several dominant alleles, including lethal yellow (Ay), result in the exclusive …

Sclerostin is an osteocyte‐derived negative regulator of bone formation. It inhibits BMP‐
stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling …

Primary DNA damage sensing in mammalian global genome nucleotide excision repair (GG-
NER) is performed by the xeroderma pigmentosum group C (XPC)/HR23B protein complex …

The WD40-repeat protein DDB2 is essential for efficient recognition and subsequent
removal of ultraviolet (UV)-induced DNA lesions by nucleotide excision repair (NER) …

Previous studies point to the XPC-hHR23B complex as the principal initiator of global
genome nucleotide excision repair (NER) pathway, responsible for the repair of UV-induced …