User profiles for "author:George Fountzilas"

GEORGE FOUNTZILAS

Professor Emeritus, Aristotle University of Thessaloniki
Verified email at auth.gr
Cited by 32130

Trastuzumab in the adjuvant treatment of early-stage breast cancer: a systematic review and meta-analysis of randomized controlled trials

IJ Dahabreh, H Linardou, F Siannis, G Fountzilas… - The …, 2008 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to:
Summarize the main characteristics and findings of randomized controlled trials evaluating …

Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a …

W De Roock, B Claes, D Bernasconi… - The lancet …, 2010 - thelancet.com
Background Following the discovery that mutant KRAS is associated with resistance to anti-
epidermal growth factor receptor (EGFR) antibodies, the tumours of patients with metastatic …

The upgraded role of HER3 and HER4 receptors in breast cancer

AK Koutras, G Fountzilas, KT Kalogeras… - Critical reviews in …, 2010 - Elsevier
The human epidermal growth factor receptor (HER) family comprises four homologous
members. The activation of these receptors affects essential tumorigenic processes and …

[HTML][HTML] Prognostic significance of autoimmunity during treatment of melanoma with interferon

H Gogas, J Ioannovich, U Dafni… - … England Journal of …, 2006 - Mass Medical Soc
Background Immunotherapy for advanced melanoma induces serologic and clinical
manifestations of autoimmunity. We assessed the prognostic significance of autoimmunity in …

Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis

P Blanchard, A Lee, S Marguet, J Leclercq… - The lancet …, 2015 - thelancet.com
Background A previous individual patient data meta-analysis by the Meta-Analysis of
Chemotherapy in Nasopharynx Carcinoma (MAC-NPC) collaborative group to assess the …

[HTML][HTML] Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer

FJ Couch, SN Hart, P Sharma, AE Toland… - Journal of clinical …, 2015 - ncbi.nlm.nih.gov
Purpose Recent advances in DNA sequencing have led to the development of breast cancer
susceptibility gene panels for germline genetic testing of patients. We assessed the …

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled …

M Martin, FA Holmes, B Ejlertsen, S Delaloge… - The lancet …, 2017 - thelancet.com
Background ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine
kinase inhibitor, significantly improves 2-year invasive disease-free survival after …

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

B Lacas, A Carmel, C Landais, SJ Wong… - Radiotherapy and …, 2021 - Elsevier
Abstract Background and purpose The Meta-Analysis of Chemotherapy in squamous cell
Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) …

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

CM Phelan, KB Kuchenbaecker, JP Tyrer, SP Kar… - Nature …, 2017 - nature.com
To identify common alleles associated with different histotypes of epithelial ovarian cancer
(EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC …

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

CA Haiman, GK Chen, CM Vachon, F Canzian… - Nature …, 2011 - nature.com
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of
African ancestry compared to women of European ancestry. In search of common risk alleles …