The advent of Precision Medicine has globally revolutionized the approach of translational
research suggesting a patient-centric vision with therapeutic choices driven by the …

Angiogenesis is a complex biological process that plays a relevant role in sustaining the
microenvironment, growth, and metastatic potential of several tumors, including non-small …

Abstract Treatment of small cell lung cancer (SCLC) remains a significant challenge for the
oncologists. Attempts to improve the results of first-line treatment have all failed so far and no …

Purpose Information about symptomatic toxicities of anticancer treatments is not based on
direct report by patients, but rather on reports by clinicians in trials. Given the potential for …

Background Inhibition of angiogenesis is a valuable treatment strategy for ovarian cancer.
Pazopanib is an anti-angiogenic drug active in ovarian cancer. We assessed the effect of …

Purpose: The resistance to selective EGFR inhibitors involves the activation of alternative
signaling pathways, and Akt activation and VEGF induction have been described in EGFR …

Background Bevacizumab is approved in combination with chemotherapy for the treatment
of ovarian cancer, either in first-line therapy or for patients with recurrent disease not …

Background The European Association for the Study of the Liver (EASL) criteria and the
modified Response Evaluation Criteria in Solid Tumors (mRECIST) are currently adopted to …

Background Uncertainty exists about the optimal schedule of adjuvant treatment of breast
cancer with aromatase inhibitors and, to our knowledge, no trial has directly compared the …

Background• Bevacizumab added to first line carboplatin and paclitaxel chemotherapy and
as maintenance prolongs PFS in patients with stage IIIB-IV ovarian cancer• In recurrent …