Brain Derived Neurotrophic Factor (BDNF) has been associated with the pathophysiology of
schizophrenia (SCZ). However, it remains unclear whether alterations in BDNF observed in …

Incidence, mortality and survival trends for the most frequent cancers affecting women are
presented on a worldwide basis. Data sources are represented by several different cancer …

Background Although the value of primary cytoreductive surgery for epithelial ovarian
cancer is beyond doubt, the value of debulking surgery after induction chemotherapy has …

PURPOSE Topotecan is a topoisomerase I inhibitor with preclinical activity against various
tumor types. We conducted a large multicenter phase II study with topotecan in ovarian …

Patients with high-risk endometrial carcinoma (stage IcG3, IIG3 with myometrial invasion>
50%, and III) receive adjuvant therapy after surgery but it is not clear whether radiotherapy …

Background: The role of systematic aortic and pelvic lymphadenectomy in patients with
optimally debulked advanced ovarian cancer is unclear and has not been addressed by …

BACKGROUND: Several lines of evidence suggest that major depressive disorder is
associated with deficits in γ-aminobutyric acid (GABA) inhibitory neurotransmission …

Background Combination chemotherapy yields better response rates which do not always
lead to a survival advantage. The aim of this study was to investigate whether the reported …

Ondansetron (OND) is a new 5-HT3 receptor antagonist that give complete protection from
emesis/nausea in approximately 50% of cisplatin (CDDP)-treated patients. To evaluate if …

Summary Background From 1983 to 1990, 271 consecutive patients with stage I ovarian
cancer entered two randomised trials, aimed at assessing the role of adjuvant chemotherapy …