Administration of cis-dichlorodiammineplatinum (II) may be associated with a number of
serious side effects, including nephrotoxicity, gastroeintestinal side effects (nausea …

Daunomycin, like its anthracycline analog adriamycin, is a cardiotoxic antitumor antibiotic.
Reports on 5,613 patients receiving daunomycin were reviewed for cardiotoxlcity. Two …

Cis-diamminedichloroplatinum (II)(DDP) leads the series of platinum coordination
complexes, a new class of cytotoxic agents. The antitumor and toxic effects of this drug are …

Potential risk factors responsible for development of doxorubicin-induced congestive heart
failure were examined through retrospective analysis of 4018 patient records. The overall …

Purpose Conflicting results on prognostic factors for advanced epithelial ovarian cancer
(EOC) have been reported because of small sample size and heterogeneity of study …

Background The indications for pegylated liposomal doxorubicin (doxil) are expanding. We,
therefore, wished to assess the safety of delivering doses exceeding 500 mg/m 2 of doxil to …

PURPOSE A phase II study of liposomal doxorubicin was conducted in patients with ovarian
cancer who failed to respond to platinum-and paclitaxel-based regimens. Liposomal …

PURPOSE: To assess progression-free survival (PFS) and overall survival (OS) in patients
with suboptimally debulked epithelial ovarian cancer receiving cisplatin (100 mg/m2) or 24 …

A total of 343 patients with previously untreated metastatic measurable colorectal carcinoma
were studied to evaluate the impact on toxicity, response, and survival of leucovorin …

Abstract Background Pegylated liposomal doxorubicin (Doxil®) has been reported to cause
immediate hypersensitivity reactions (HSRs) that cannot be explained as IgE-mediated (type …