Background BRCA1 methylation has been associated with homologous recombination
deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal …

High‐grade serous ovarian cancer (HGSOC) likely originates from the fallopian tube (FT)
epithelium. Here, we established 15 organoid lines from HGSOC primary tumor deposits that …

Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring
and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr …

During the development of cancer, changes in cellular glycosylation are observed,
indicating that alterations of the glycome occur in extracellular fluids as well as in serum and …

Objective The tumor suppressor p53 generates the N-terminally truncated isoforms Δ40p53
and Δ133p53 that possess the ability to modulate p53 function in vitro. The aim of the …

TP53 is the most commonly mutated gene in cancer and has been shown to form amyloid-
like aggregates, similar to key proteins in neurodegenerative diseases. Nonetheless, the …

Background High-grade serous ovarian cancer (HGSOC) is the most common subtype of
ovarian cancer and is associated with high mortality rates. Surgical outcome is one of the …

Background: The PRIMA phase 3 trial showed niraparib significantly prolongs median
progression-free survival (PFS) versus placebo in patients with advanced ovarian cancer …

Epithelial ovarian cancer (EOC) is worldwide the sixth most lethal form of cancer occurring in
women. More than one third of ovarian patients have ascites at the time of diagnosis and …

Mechanisms of intrinsic resistance of serous ovarian cancers to standard treatment with
carboplatin and paclitaxel are poorly understood. Seventeen primary serous ovarian …