[HTML][HTML] The pig as a model for translational research: overview of porcine animal models at Jichi Medical University
E Kobayashi, S Hishikawa, T Teratani, AT Lefor - Transplantation research, 2012 - Springer
To improve the welfare of experimental animals, investigators seek to respect the 3R
principle (Replacement, Reduction, and Refinement). Even when large animal studies are …
principle (Replacement, Reduction, and Refinement). Even when large animal studies are …
Biomarkers for screening, diagnosis, and monitoring of ovarian cancer
E Kobayashi, Y Ueda, S Matsuzaki, T Yokoyama… - … Biomarkers & Prevention, 2012 - AACR
Serum tumor markers have a major role in the screening, diagnosis, and monitoring of most
of the gynecologic cancers. Ovarian cancer is one of the deadliest of the group because it is …
of the gynecologic cancers. Ovarian cancer is one of the deadliest of the group because it is …
[HTML][HTML] Completion of the swine genome will simplify the production of swine as a large animal biomedical model
Background Anatomic and physiological similarities to the human make swine an excellent
large animal model for human health and disease. Methods Cloning from a modified …
large animal model for human health and disease. Methods Cloning from a modified …
Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C
E Kobayashi, H Nakano, M Morimoto… - … and biophysical research …, 1989 - Elsevier
Abstract Calphostin C (UCN-1028C), a newly isolated compound from Cladosporium
cladosporioides, is a potent and specific inhibitor of protein kinase C, because it was 1000 …
cladosporioides, is a potent and specific inhibitor of protein kinase C, because it was 1000 …
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
T Koga, M Inui, K Inoue, S Kim, A Suematsu… - Nature, 2004 - nature.com
Costimulatory signals are required for activation of immune cells, but it is not known whether
they contribute to other biological systems. The development and homeostasis of the …
they contribute to other biological systems. The development and homeostasis of the …
Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues
Recently, the field of tissue engineering has progressed rapidly, but poor vascularization
remains a major obstacle in bioengineering cell‐dense tissues, limiting the viable size of …
remains a major obstacle in bioengineering cell‐dense tissues, limiting the viable size of …
[HTML][HTML] In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels
In vitro fabrication of functional vascularized three-dimensional tissues has been a long-
standing objective in the field of tissue engineering. Here we report a technique to engineer …
standing objective in the field of tissue engineering. Here we report a technique to engineer …
Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts
Background—Regenerative therapies, including myocardial tissue engineering, have been
pursued as a new possibility to repair the damaged myocardium, and previously the …
pursued as a new possibility to repair the damaged myocardium, and previously the …
Cardiac cell sheet transplantation improves damaged heart function via superior cell survival in comparison with dissociated cell injection
Regenerative therapies have currently emerged as one of the most promising treatments for
repair of the damaged heart. Recently, numerous researchers reported that isolated cell …
repair of the damaged heart. Recently, numerous researchers reported that isolated cell …
Intra-articular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat …
M Horie, I Sekiya, T Muneta, S Ichinose… - Stem …, 2009 - academic.oup.com
Osteoarthritis in the knees, which can be caused by meniscal defect, constitutes an
increasingly common medical problem. Repair for massive meniscal defect remains a …
increasingly common medical problem. Repair for massive meniscal defect remains a …