Renal toxicity is a prominent component of the toxicity profile of platinum-based
chemotherapy. Kidney damage, once dose limiting for cisplatin, occurs in some patients who …

Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form
of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum …

Cisplatin is one of the most potent anticancer agents, displaying significant clinical activity
against a variety of solid tumors. For more than two decades, the most effective systemic …

PURPOSE: Prostate-specific antigen (PSA) is a glycoprotein that is found almost exclusively
in normal and neoplastic prostate cells. For patients with metastatic disease, changes in …

The present study was designed to explore the activity of platinum compounds in
cisplatinresistant cell lines, the unselected cell lines of the National Cancer Institute's …

Nucleotide excision repair is a DNA repair pathway that is highly conserved in nature, with
analogous repair systems described in Escherichia coli, yeast, and mammalian cells. The …

Objective: To describe platinum-based chemotherapy combined with local treatment
modalities as an alternative to external beam radiotherapy for intraocular retinoblastoma …

The thrust of the experimental data presented here is that small air ions are biologically
active. There is convincing evidence that both negative and positive ions (i) inhibit growth of …

Lovastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase
(the major regulatory enzyme of the mevalonate pathway of cholesterol synthesis), displays …

Studies were undertaken to investigate acquired resistance to cisplatin in human ovarian
cancer cells. The cell lines A2780 and A2780/CP70 were studied to assess their respective …