OBJECTIVE: Retinoids are important modulators of cell growth, differentiation, and
proliferation. 9cUAB30, 9cUAB124, and 9cUAB130 are three novel retinoid compounds that …

The complete 1H nuclear magnetic resonance assignments have been made for the
common mono-, di-, and trihydroxy 5 beta-cholanoic acids; lithocholic acid …

Retinoid X receptors (RXRs) are obligate partners for several other nuclear receptors, and
they play a key role in several signaling processes. Despite being a promiscuous …

Most cases of cystic fibrosis (CF) are caused by mutations that block the biosynthetic
maturation of the CF gene product, the CF transmembrane conductance regulator (CFTR) …

We recently synthesized several conformationally constrained retinoic acid (RA) analogues
[8-(2 '-cyclohexen-1 '-ylidene)-3, 7-dimethyl-2, 4, 6-octatrienoic acids with different alkyl …

Increasing evidence suggests heterogeneity in the molecular pathogenesis of cystic fibrosis
(CF). Mutations such as deletion of phenylalanine at position 508 (delta F508) within the …

Materials and Methods Purple Membrane Preparation. Halobacterium halobium S9 was
grown in a laboratory-built fermentor equipped with fluorescent lights. The purple membrane …

A number of retinoid X receptor (RXR) agonists have proven to be highly effective in
preventing methylnitrosourea (MNU) induced mammary cancers. However, these agonists …

purpose. The release of N-acetyl-proline-glycine-proline (PGP), a chemoattractant resulting
from direct alkaline hydrolysis of corneal proteins, is believed to be the initial trigger for …

Examination of three retinoid X receptor (RXR) agonists [Targretin (TRG), UAB30, and 4-
methyl-UAB30 (4-Me-UAB30)] showed that all inhibited mammary cancer in rodents and two …