There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …

The classification of epithelial ovarian cancer has been substantially revised, with an
increased appreciation of the cellular origins and molecular aberrations of the different …

Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis,
but the molecular events involved in this transformation have not been described. Methods …

Cancer develops through a process of somatic evolution,. Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

Because of the high risk of recurrence in high-grade serous ovarian carcinoma (HGS-OvCa),
the development of outcome predictors could be valuable for patient stratification. Using the …

Histone deacetylase inhibitors (HDACis) inhibit tumor cell growth and survival, possibly
through their ability to regulate the expression of specific proliferative and/or apoptotic …

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy,
responsible for 13 000 deaths per year in the United States. Risk prediction based on …

Background Few biomarkers of ovarian cancer prognosis have been established, partly
because subtype-specific associations might be obscured in studies combining all …

Abstract Hypoxia-inducible factor-1α (HIF1α) is a central regulator of the cellular response to
hypoxia. Prolyl-hydroxylation of HIF1α by PHD enzymes is prerequisite for HIF1α …