[HTML][HTML] Isolation and retrieval of circulating tumor cells using centrifugal forces
Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer
patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral …
patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral …
Selpercatinib in Patients With RET Fusion–Positive Non–Small-Cell Lung Cancer: Updated Safety and Efficacy From the Registrational LIBRETTO-001 Phase I/II Trial
PURPOSE Selpercatinib, a first-in-class, highly selective, and potent CNS-active RET kinase
inhibitor, is currently approved for the treatment of patients with RET fusion–positive non …
inhibitor, is currently approved for the treatment of patients with RET fusion–positive non …
[HTML][HTML] Advances in systemic treatment for nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a unique disease endemic in Asia. It is etiologically
linked to the Epstein-Barr virus and is both radio-and chemo-sensitive. While radiotherapy …
linked to the Epstein-Barr virus and is both radio-and chemo-sensitive. While radiotherapy …
Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous …
Background We evaluated the efficacy and safety of tepotinib, a potent and highly selective
oral MET inhibitor, plus gefitinib in patients with epidermal growth factor receptor (EGFR) …
oral MET inhibitor, plus gefitinib in patients with epidermal growth factor receptor (EGFR) …
[HTML][HTML] Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells
The enumeration and characterization of circulating tumor cells (CTCs), found in the
peripheral blood of cancer patients, provide a potentially accessible source for cancer …
peripheral blood of cancer patients, provide a potentially accessible source for cancer …
Genomic landscape of lung adenocarcinoma in East Asians
J Chen, H Yang, ASM Teo, LB Amer, FG Sherbaf… - Nature …, 2020 - nature.com
Lung cancer is the world's leading cause of cancer death and shows strong ancestry
disparities. By sequencing and assembling a large genomic and transcriptomic dataset of …
disparities. By sequencing and assembling a large genomic and transcriptomic dataset of …
Single‐cell profiling approaches to probing tumor heterogeneity
Tumor heterogeneity is a major hindrance in cancer classification, diagnosis and treatment.
Recent technological advances have begun to reveal the true extent of its heterogeneity …
Recent technological advances have begun to reveal the true extent of its heterogeneity …
Methionine is a metabolic dependency of tumor-initiating cells
Understanding cellular metabolism holds immense potential for developing new classes of
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
therapeutics that target metabolic pathways in cancer. Metabolic pathways are altered in …
[HTML][HTML] Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells
Background Circulating tumor cells (CTCs) are cancer cells that can be isolated via liquid
biopsy from blood and can be phenotypically and genetically characterized to provide …
biopsy from blood and can be phenotypically and genetically characterized to provide …
An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells
The detection and characterization of rare circulating tumor cells (CTCs) from the blood of
cancer patients can potentially provide critical insights into tumor biology and hold great …
cancer patients can potentially provide critical insights into tumor biology and hold great …