Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance—a study of the OVCAD consortium
E Obermayr, DC Castillo-Tong, D Pils, P Speiser… - Gynecologic …, 2013 - Elsevier
OBJECTIVE: The study aims at identifying novel markers for circulating tumor cells (CTCs) in
patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome …
patients with epithelial ovarian cancer (EOC), and at evaluating their impact on outcome …
Prognostic value of residual tumor size in patients with epithelial ovarian cancer FIGO stages IIA–IV: analysis of the OVCAD data
Objective The objective of the study was to evaluate the prognostic impact of residual tumor
size after cytoreductive surgery in patients with epithelial ovarian cancer. Methods In this …
size after cytoreductive surgery in patients with epithelial ovarian cancer. Methods In this …
USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability
M Sonego, I Pellarin, A Costa, GLR Vinciguerra… - Science …, 2019 - science.org
Resistance to platinum-based chemotherapy is a common event in patients with cancer,
generally associated with tumor dissemination and metastasis. Whether platinum treatment …
generally associated with tumor dissemination and metastasis. Whether platinum treatment …
Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in patients with ovarian cancer
JM Flanagan, A Wilson, C Koo, N Masrour… - Clinical Cancer …, 2017 - AACR
Purpose: DNA damage repair can lead to epigenetic changes. DNA mismatch repair
proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA …
proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA …
[HTML][HTML] Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients-a study of the OVCAD consortium
A Bachmayr-Heyda, S Aust, G Heinze, S Polterauer… - BMC cancer, 2013 - Springer
Background Epithelial ovarian cancer is one of the most lethal gynecologic malignancies.
Clinicopathological factors do not permit precise prognosis and cannot provide guidance to …
Clinicopathological factors do not permit precise prognosis and cannot provide guidance to …
[HTML][HTML] Cyclin E1 (CCNE1) as independent positive prognostic factor in advanced stage serous ovarian cancer patients–a study of the OVCAD consortium
D Pils, A Bachmayr-Heyda, K Auer, M Svoboda… - European journal of …, 2014 - Elsevier
Cyclin E, coded by the genes CCNE1 and CCNE2, is the main regulator for transition from G
1 to S phase determining cell division. CCNE1 and CCNE2 are known oncogenes in many …
1 to S phase determining cell division. CCNE1 and CCNE2 are known oncogenes in many …
[HTML][HTML] Genetic heterogeneity after first-line chemotherapy in high-grade serous ovarian cancer
S Lambrechts, D Smeets, M Moisse, EI Braicu… - European Journal of …, 2016 - Elsevier
Background Most high-grade serous ovarian carcinoma (HGSOC) patients benefit from first-
line platinum-based chemotherapy, but progressively develop resistance during subsequent …
line platinum-based chemotherapy, but progressively develop resistance during subsequent …
[HTML][HTML] Treatment reality in elderly patients with advanced ovarian cancer: a prospective analysis of the OVCAD consortium
F Trillsch, L Woelber, C Eulenburg, I Braicu… - Journal of ovarian …, 2013 - Springer
Background Approximately one third of women diagnosed with ovarian cancer is 70 years or
older. Information on the treatment reality of these elderly patients is limited. Methods 275 …
older. Information on the treatment reality of these elderly patients is limited. Methods 275 …
[HTML][HTML] Circulating tumor cells: potential markers of minimal residual disease in ovarian cancer? a study of the OVCAD consortium
E Obermayr, N Bednarz-Knoll, B Orsetti, HU Weier… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Purpose In 75% of ovarian cancer patients the tumor mass is completely eradicated by
established surgical and cytotoxic treatment; however, the majority of the tumors recur within …
established surgical and cytotoxic treatment; however, the majority of the tumors recur within …
A complex network of tumor microenvironment in human high-grade serous ovarian cancer
C Kreuzinger, A Geroldinger, D Smeets, EI Braicu… - Clinical Cancer …, 2017 - AACR
Purpose: Most high-grade serous ovarian cancer (HGSOC) patients develop recurrent
disease after first-line treatment, frequently with fatal outcome. This work aims at studying the …
disease after first-line treatment, frequently with fatal outcome. This work aims at studying the …