We herein present an overview of the upcoming 5th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers …

Computational modeling of biological systems is challenging because of the multitude of
spatial and temporal scales involved. Replacing atomistic detail with lower resolution …

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Adaptive features of innate immunity, recently described as “trained immunity,” have been
documented in plants, invertebrate animals, and mice, but not yet in humans. Here we show …

The Martini coarse-grained force field has been successfully used for simulating a wide
range of (bio) molecular systems. Recent progress in our ability to test the model against …

Ulcerative colitis is a chronic, relapsing inflammatory condition of the gastrointestinal tract
with a complex genetic and environmental etiology. In an effort to identify genetic variation …

Purpose Classical Hodgkin lymphomas (cHLs) include small numbers of malignant Reed-
Sternberg cells within an extensive but ineffective inflammatory/immune cell infiltrate. In cHL …

Cyclin D1 overexpression is believed to be essential in the pathogenesis of mantle cell
lymphoma (MCL). Hence, the existence of cyclin D1-negative MCL has been controversial …

Most invasive breast cancers are classified as invasive ductal carcinoma not otherwise
specified (IDC NOS), whereas about 25% are defined as histological 'special types'. These …