Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

C von Haefen, T Wieder, B Gillissen, L Stärck… - Oncogene, 2002 - nature.com
The intracellular pathways leading to mitochondrial activation and subsequent cell death in
the ceramide-mediated stress response have been intensively studied in recent years …

Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

C von Haefen, T Wieder, F Essmann, K Schulze-Osthoff… - Oncogene, 2003 - nature.com
Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we
demonstrated, however, that caspase-8 can also be activated in a death receptor …

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

K Friedrich, T Wieder, C Von Haefen, S Radetzki… - Oncogene, 2001 - nature.com
In this study, we asked whether overexpression of caspase-3, a central downstream
executioner of apoptotic pathways, might sensitize breast cancer cells with acquired drug …

[HTML][HTML] Acetylcholinesterase inhibitors reduce neuroinflammation and-degeneration in the cortex and hippocampus of a surgery stress rat model

A Kalb, C von Haefen, M Sifringer, A Tegethoff… - PLoS …, 2013 - journals.plos.org
Exogenous stress like tissue damage and pathogen invasion during surgical trauma could
lead to a peripheral inflammatory response and induce neuroinflammation, which can result …

[HTML][HTML] Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain

S Endesfelder, H Makki, C von Haefen, CD Spies… - PLoS …, 2017 - journals.plos.org
Dexmedetomidine (DEX) is a highly selective agonist of α2-receptors with sedative,
anxiolytic, and analgesic properties. Neuroprotective effects of dexmedetomidine have been …

[HTML][HTML] Neuroprotective effect of dexmedetomidine on hyperoxia-induced toxicity in the neonatal rat brain

M Sifringer, C von Haefen, M Krain… - … medicine and cellular …, 2015 - hindawi.com
Dexmedetomidine is a highly selective agonist of α2-receptors with sedative, anxiolytic,
analgesic, and anesthetic properties. Neuroprotective effects of dexmedetomidine have …

Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis

PG Hemmati, B Gillissen, C von Haefen, J Wendt… - Oncogene, 2002 - nature.com
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …

Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brain

M Sifringer, D Brait, U Weichelt, G Zimmerman… - Brain, behavior, and …, 2010 - Elsevier
Oxygen toxicity contributes to the pathogenesis of adverse neurological outcome in
survivors of preterm birth in clinical studies. In infant rodent brains, hyperoxia triggers …

[HTML][HTML] Dexmedetomidine prevents lipopolysaccharide-induced microRNA expression in the adult rat brain

N Paeschke, C Von Haefen, S Endesfelder… - International journal of …, 2017 - mdpi.com
During surgery or infection, peripheral inflammation can lead to neuroinflammation, which is
associated with cognitive impairment, neurodegeneration, and several neurodegenerative …

[HTML][HTML] Circadian rhythms in septic shock patients

G Lachmann, B Ananthasubramaniam… - Annals of intensive …, 2021 - Springer
Background Despite the intensive efforts to improve the diagnosis and therapy of sepsis
over the last decade, the mortality of septic shock remains high and causes substantial …