[HTML][HTML] Chemoradiotherapy with or without cetuximab in patients with oesophageal cancer (SCOPE1): a multicentre, phase 2/3 randomised trial
T Crosby, CN Hurt, S Falk, S Gollins… - The lancet …, 2013 - thelancet.com
Background Definitive chemoradiotherapy (CRT) is an alternative to surgery for the curative
treatment of oesophageal carcinoma. The SCOPE1 trial aimed to investigate the addition of …
treatment of oesophageal carcinoma. The SCOPE1 trial aimed to investigate the addition of …
[HTML][HTML] Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial
S Mukherjee, CN Hurt, J Bridgewater, S Falk… - The lancet …, 2013 - thelancet.com
Background In the UK, chemotherapy is the standard treatment for inoperable, locally
advanced, non-metastatic pancreatic cancer. Chemoradiotherapy is also an acceptable …
advanced, non-metastatic pancreatic cancer. Chemoradiotherapy is also an acceptable …
[HTML][HTML] Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT3VIN): a multicentre, open-label, randomised …
A Tristram, CN Hurt, T Madden, N Powell… - The Lancet …, 2014 - thelancet.com
Background Vulval intraepithelial neoplasia is a skin disorder affecting the vulva that, if left
untreated, can become cancerous. Currently, the standard treatment for patients with vulval …
untreated, can become cancerous. Currently, the standard treatment for patients with vulval …
[HTML][HTML] SCOPE1: a randomised phase II/III multicentre clinical trial of definitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus
CN Hurt, LS Nixon, GO Griffiths, R Al-Mokhtar, S Gollins… - BMC cancer, 2011 - Springer
Background Chemoradiotherapy is the standard of care for patients with oesophageal
cancer unsuitable for surgery due to the presence of co-morbidity or extent of disease, and is …
cancer unsuitable for surgery due to the presence of co-morbidity or extent of disease, and is …
Recurrence of vulval intraepithelial neoplasia following treatment with cidofovir or imiquimod: results from a multicentre, randomised, phase II trial (RT 3 VIN)
Objective To compare the recurrence rates after complete response to topical treatment with
either cidofovir or imiquimod for vulval intraepithelial neoplasia (VIN) 3. Design A …
either cidofovir or imiquimod for vulval intraepithelial neoplasia (VIN) 3. Design A …
[HTML][HTML] Health-related quality of life in SCALOP, a randomized phase 2 trial comparing chemoradiation therapy regimens in locally advanced pancreatic cancer
CN Hurt, S Mukherjee, J Bridgewater, S Falk… - International Journal of …, 2015 - Elsevier
Purpose Chemoradiation therapy (CRT) for patients with locally advanced pancreatic cancer
(LAPC) provides survival benefits but may result in considerable toxicity. Health-related …
(LAPC) provides survival benefits but may result in considerable toxicity. Health-related …
[HTML][HTML] NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based …
S Mukherjee, CN Hurt, S Gwynne, A Bateman… - BMC cancer, 2015 - Springer
Background Both oxaliplatin/capecitabine-based chemoradiation (OXCAP-RT) and
carboplatin-paclitaxel based radiation (CarPac-RT) are active regimens in oesophageal …
carboplatin-paclitaxel based radiation (CarPac-RT) are active regimens in oesophageal …
[HTML][HTML] Potential of proton therapy to reduce acute hematologic toxicity in concurrent chemoradiation therapy for esophageal cancer
S Warren, CN Hurt, T Crosby, M Partridge… - International Journal of …, 2017 - Elsevier
Purpose Radiation therapy dose escalation using a simultaneous integrated boost (SIB) is
predicted to improve local tumor control in esophageal cancer; however, any increase in …
predicted to improve local tumor control in esophageal cancer; however, any increase in …
Human papillomavirus DNA methylation predicts response to treatment using cidofovir and imiquimod in vulval intraepithelial neoplasia 3
Purpose: Response rates to treatment of vulval intraepithelial neoplasia (VIN) with
imiquimod and cidofovir are approximately 57% and 61%, respectively. Treatment is …
imiquimod and cidofovir are approximately 57% and 61%, respectively. Treatment is …
[HTML][HTML] Circulating biomarkers and outcomes from a randomised phase 2 trial of gemcitabine versus capecitabine-based chemoradiotherapy for pancreatic cancer
F Willenbrock, CM Cox, EE Parkes… - British Journal of …, 2021 - nature.com
Abstract Background The Phase 2 SCALOP trial compared gemcitabine with capecitabine-
based consolidation chemoradiotherapy (CRT) in locally advanced pancreatic cancer …
based consolidation chemoradiotherapy (CRT) in locally advanced pancreatic cancer …