User profiles for "author:C Westphalen"

C. Benedikt Westphalen

Medical Lead Precision Oncology
Verified email at med.lmu.de
Cited by 9476

[HTML][HTML] Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working …

F Mosele, J Remon, J Mateo, CB Westphalen… - Annals of …, 2020 - Elsevier
Next-generation sequencing (NGS) allows sequencing of a high number of nucleotides in a
short time frame at an affordable cost. While this technology has been widely implemented …

Delivering precision oncology to patients with cancer

J Mateo, L Steuten, P Aftimos, F André, M Davies… - Nature medicine, 2022 - nature.com
With the increasing use of genomic profiling for diagnosis and therapy guidance in many
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …

Genetically engineered mouse models of pancreatic cancer

CB Westphalen, KP Olive - The Cancer Journal, 2012 - journals.lww.com
Pancreatic ductal adenocarcinoma is the 10th most common cancer and the fourth leading
cause of cancer-related death in the United States. Despite great effort, the prognosis for …

[HTML][HTML] Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

AD Rhim, PE Oberstein, DH Thomas, ET Mirek… - Cancer cell, 2014 - cell.com
Sonic hedgehog (Shh), a soluble ligand overexpressed by neoplastic cells in pancreatic
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …

[HTML][HTML] Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential

DL Worthley, M Churchill, JT Compton, Y Tailor, M Rao… - Cell, 2015 - cell.com
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …

Denervation suppresses gastric tumorigenesis

CM Zhao, Y Hayakawa, Y Kodama… - Science translational …, 2014 - science.org
The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …

[PDF][PDF] Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling

Y Hayakawa, K Sakitani, M Konishi, S Asfaha… - Cancer cell, 2017 - cell.com
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …

[PDF][PDF] β2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer

BW Renz, R Takahashi, T Tanaka, M Macchini… - Cancer cell, 2018 - cell.com
Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling
in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines …

Projections of cancer incidence and cancer‐related deaths in Germany by 2020 and 2030

AS Quante, C Ming, M Rottmann, J Engel… - Cancer …, 2016 - Wiley Online Library
Past patterns of cancer disease and future changes in the demographic structure have a
major influence on the projected incidences of human malignancies. In Germany, nearly a …

[PDF][PDF] Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche

Y Hayakawa, H Ariyama, J Stancikova, K Sakitani… - Cancer cell, 2015 - cell.com
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain.
Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus …