User profiles for "author:C Westphalen"
C. Benedikt WestphalenMedical Lead Precision Oncology Verified email at med.lmu.de Cited by 9476 |
[HTML][HTML] Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working …
Next-generation sequencing (NGS) allows sequencing of a high number of nucleotides in a
short time frame at an affordable cost. While this technology has been widely implemented …
short time frame at an affordable cost. While this technology has been widely implemented …
Delivering precision oncology to patients with cancer
With the increasing use of genomic profiling for diagnosis and therapy guidance in many
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …
Genetically engineered mouse models of pancreatic cancer
CB Westphalen, KP Olive - The Cancer Journal, 2012 - journals.lww.com
Pancreatic ductal adenocarcinoma is the 10th most common cancer and the fourth leading
cause of cancer-related death in the United States. Despite great effort, the prognosis for …
cause of cancer-related death in the United States. Despite great effort, the prognosis for …
[HTML][HTML] Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
Sonic hedgehog (Shh), a soluble ligand overexpressed by neoplastic cells in pancreatic
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …
ductal adenocarcinoma (PDAC), drives formation of a fibroblast-rich desmoplastic stroma …
[HTML][HTML] Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …
suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts …
Denervation suppresses gastric tumorigenesis
CM Zhao, Y Hayakawa, Y Kodama… - Science translational …, 2014 - science.org
The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …
[PDF][PDF] Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling
Y Hayakawa, K Sakitani, M Konishi, S Asfaha… - Cancer cell, 2017 - cell.com
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …
[PDF][PDF] β2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer
BW Renz, R Takahashi, T Tanaka, M Macchini… - Cancer cell, 2018 - cell.com
Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling
in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines …
in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines …
Projections of cancer incidence and cancer‐related deaths in Germany by 2020 and 2030
Past patterns of cancer disease and future changes in the demographic structure have a
major influence on the projected incidences of human malignancies. In Germany, nearly a …
major influence on the projected incidences of human malignancies. In Germany, nearly a …
[PDF][PDF] Mist1 expressing gastric stem cells maintain the normal and neoplastic gastric epithelium and are supported by a perivascular stem cell niche
Y Hayakawa, H Ariyama, J Stancikova, K Sakitani… - Cancer cell, 2015 - cell.com
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain.
Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus …
Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus …