Advanced-inoperable cervical cancer is a challenging entity due to increased percentage of
locoregional and distant recurrences. Furthermore, recurrent cervical cancer not amenable …

Standard therapy for platinum-resistant ovarian cancer (OC) is single-agent chemotherapy.
The most active single agents are pegylated liposomal doxorubicin, paclitaxel, and …

Background Few options exist for patients with locally advanced or metastatic urothelial
carcinoma after progression with platinum-based chemotherapy. We aimed to assess the …

Background Atezolizumab can induce sustained responses in metastatic urothelial
carcinoma. We report the results of IMvigor130, a phase 3 trial that compared atezolizumab …

Background The role of adjuvant treatment in high-risk muscle-invasive urothelial carcinoma
after radical surgery is not clear. Methods In a phase 3, multicenter, double-blind …

Background Survival outcomes are poor for patients with metastatic urothelial carcinoma
who receive standard, first-line, platinum-based chemotherapy. We assessed the overall …

Background No new agent has improved overall survival in patients with unresectable or
metastatic urothelial carcinoma when added to first-line cisplatin-based chemotherapy …

Background The efficacy and safety of cabazitaxel, as compared with an androgen-signaling–
targeted inhibitor (abiraterone or enzalutamide), in patients with metastatic castration …

Background The benefit of cytoreductive nephrectomy (CN) for overall survival (OS) is
unclear in patients with synchronous metastatic renal cell carcinoma (mRCC) in the era of …

Osteonecrosis of the jaw (ONJ) has been associated with the use of pamidronate and
zoledronic acid. ONJ was assessed prospectively since July 2003 in 202 patients with …