Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors

…, DG Mutch, ME Carney, A Berchuck, BJN Winterhoff… - Nature medicine, 2017 - nature.com
It is generally assumed that recurrent mutations within a given cancer driver gene elicit
similar drug responses. Cancer genome studies have identified recurrent but divergent …

The effect of photobiomodulation on chemotherapy-induced peripheral neuropathy: A randomized, sham-controlled clinical trial

…, R Ghebre, SA Mullany, DGK Teoh, BJN Winterhoff… - Gynecologic …, 2017 - Elsevier
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect
of cancer therapy with few efficacious treatments. Methods We enrolled 70 patients with …

Bevacizumab and improvement of progression-free survival (PFS) for patients with the mesenchymal molecular subtype of ovarian cancer.

BJN Winterhoff, S Kommoss, AL Oberg, C Wang… - 2014 - ascopubs.org
5509 Background: ICON7 demonstrated that the addition of bevacizumab to carboplatin and
paclitaxel improves progression free survival (PFS), but not overall survival (OS) in first-line …

Characterisation of FAP-1 expression and CD95 mediated apoptosis in the A818-6 pancreatic adenocarcinoma differentiation system

BJN Winterhoff, A Arlt, A Duttmann, H Ungefroren… - Differentiation, 2012 - Elsevier
The present study investigated the expression and localisation of FAP-1 (Fas associated
phosphatase-1) and CD95 in a 3D differentiation model in comparison to 2D monolayers of …

Prediction of post-operative residual disease in advanced-stage ovarian cancer (AOC) using whole transcriptome expression: An exploratory analysis of the AGO …

F Heitz, S Kommoss, BJN Winterhoff, C Aliferis… - 2018 - ascopubs.org
5550 Background: Complete resection (CR) at primary debulking surgery is the single most
important prognostic factor in AOC. It has been demonstrated, that suboptimal debulking …

Significant overall survival improvement in proliferative subtype ovarian cancer patients receiving bevacizumab.

S Kommoss, F Heitz, BJN Winterhoff, C Wang… - 2018 - ascopubs.org
5520 Background: We previously demonstrated that bevacizumab may differentially improve
ovarian cancer progression-free survival (PFS) depending on TCGA molecular subtypes …

Potent antitumor activity of PG545 in platinum sensitive and resistant ovarian cancer models: Correlation with increases in plasma VEGF and heparanase-implications …

BJN Winterhoff - 2014 - search.proquest.com
PG545 is a fully synthetic heparan sulfate (HS) mimetic currently in early clinical testing for
advanced cancers. This compound inhibits key processes in tumor progression including …

Dilution of molecular-pathologic gene signatures (MPG) by parameter unrelated to tumor biology (UTB) may prevent prediction of the resection status after debulking …

…, I Braicu, P Harter, SC Dowdy, BJN Winterhoff… - 2019 - ijgc.bmj.com
Introduction/Background Predicting surgical outcome could improve individualizing
treatment strategies for pts with AOC. Several earlier papers have proposed that debulking …

USP14 als prognostisch relevanter Biomarker und potentieller Kandidat für eine medikamentöse Behandlung der Endometriumkarzinompatientin mit hohem Risiko

…, R Ding, G Konecny, BJN Winterhoff… - Geburtshilfe und …, 2016 - thieme-connect.com
Zielsetzung: USP14 ist ein Enzym, das am Proteinabbau und an der Regulation wichtiger
zellulärer Prozesse beteiligt ist. Es konnte gezeigt werden, dass eine Überexpression des …

Auf dem Weg zur Präzisionsmedizin in der Gynäkologischen Onkologie

…, A Teoman, BJN Winterhoff - TumorDiagnostik & …, 2016 - thieme-connect.com
Krebs gewinnt aufgrund der immer älter werdenden Bevölkerung ständig an Bedeutung und
ist weltweit eine der häufigsten Todesursachen. Seit den frühen 90er-Jahren geht die …