Similar to p73, the tumor suppressor gene p53 is subject to alternative splicing. Besides
p53ΔE6 and p53β, we identified p53ζ, p53δ and p53ɛ, arising from alternative splicing of …

Purpose: We aimed to determine the clinical role of the p53 family members p53 and p73 in
the responsiveness to platinum-based chemotherapy and survival in ovarian cancer …

Cyclin E, coded by the genes CCNE1 and CCNE2, is the main regulator for transition from G
1 to S phase determining cell division. CCNE1 and CCNE2 are known oncogenes in many …

Objective The tumor suppressor p53 generates the N-terminally truncated isoforms Δ40p53
and Δ133p53 that possess the ability to modulate p53 function in vitro. The aim of the …

Background Although fetal size is associated with adverse perinatal outcome, the
relationship between fetal growth velocity and adverse perinatal outcome is unclear …

Introduction Following the detection of fetal growth restriction, there is no consensus about
the criteria that should trigger delivery in the late preterm period. The consequences of …

The tumor suppressor protein p53 is mutated in half of all cancers and has been described
to form amyloid-like structures, commonly known from key proteins in neurodegenerative …

Introduction Long-term survivors of ovarian cancer are a unique group of patients in whom
prognostic factors for long-term survival have been poorly described. Such factors may …

The p73 gene gives rise to the full-length transactivation competent TAp73 and the N-
terminally truncated isoform ΔNp73, which inhibits TAp73 and wild-type p53. The clinical …

There exists initial evidence for beneficial daylight effects in hospital bedrooms. However,
study results with automatically controlled dynamic bedroom lights were so far inconclusive …