Background Angiogenesis plays a role in the biology of ovarian cancer. We examined the
effect of bevacizumab, the vascular endothelial growth factor inhibitor, on survival in women …

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …

MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as
negative gene regulators. miRNA deregulation is involved in the initiation and progression …

Abstract MicroRNAs (miRNA) are approximately 22-nucleotide noncoding RNAs that
negatively regulate protein-coding gene expression in a sequence-specific manner via …

Genome-wide association studies (GWAS) have identified four susceptibility loci for
epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome …

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological
malignancy in the developed world, accounting for 4% of the deaths from cancer in women …

Inherited predisposition to breast cancer is known to be caused by loss-of-function mutations
in BRCA1, BRCA2, PALB2, CHEK2, and other genes involved in DNA repair. However, most …

The estimated lifetime risk for endometrial carcinoma (EC) in hereditary nonpolyposis
colorectal cancer syndrome (HNPCC) is 32–60%, thus supporting surveillance. The survival …

HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic
silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this …

Primary fallopian tube carcinoma (PFTC) is rare, constituting about 1% of female genital tract
malignancies, and little is known about its etiological, protective, risk or prognostic factors …