Herpes simplex virus type 1 (HSV-1)-induced apoptosis in human dendritic cells as a result of downregulation of cellular FLICE-inhibitory protein and reduced …

A Kather, MJ Raftery, G Devi-Rao, J Lippmann… - Journal of …, 2010 - Am Soc Microbiol
Herpes simplex virus type 1 (HSV-1) is one of the most frequent and successful human
pathogens. It targets immature dendritic cells (iDCs) to interfere with the antiviral immune …

[HTML][HTML] Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations

C Ammer-Herrmenau, U Kulkarni, N Andreas… - PLoS …, 2019 - journals.plos.org
Massive apoptosis of lymphocytes is a hallmark of sepsis. The resulting immunosuppression
is associated with secondary infections, which are often lethal. Moreover, sepsis-survivors …

[HTML][HTML] Characterization of a caprine model for the subclinical initial phase of Mycobacterium avium subsp. paratuberculosis infection

H Köhler, A Soschinka, M Meyer, A Kather… - BMC veterinary …, 2015 - Springer
Abstract Background Paratuberculosis caused by Mycobacterium avium subsp.
paratuberculosis (MAP) is difficult to control due to a long phase of clinically non-apparent …

[HTML][HTML] Acute postoperative pain in 23 procedures of gynaecological surgery analysed in a prospective open registry study on risk factors and consequences for the …

JJ Cruz, A Kather, K Nicolaus, M Rengsberger… - Scientific reports, 2021 - nature.com
Effective perioperative pain management is essential for optimal patient recovery after
surgery and reduces the risk of chronification. However, in clinical practice, perioperative …

Frontline: Induction of apoptosis and modulation of c‐FLIPL and p53 in immature dendritic cells infected with herpes simplex virus

DB Müller, MJ Raftery, A Kather, T Giese… - European journal of …, 2004 - Wiley Online Library
Herpes simplex virus (HSV) can perturb the function of dendritic cells (DC). The underlying
mechanisms are not defined. In the present study we demonstrate that HSV induces a …

Identification of a naturally processed HLA‐A*0201 HPV18 E7 T cell epitope by tumor cell mediated in vitro vaccination

A Kather, A Ferrara, M Nonn, M Schinz… - … journal of cancer, 2003 - Wiley Online Library
Immunotherapy of HPV‐associated disease such as cervical cancer is moving from
preclinical investigation to clinical trials. The viral oncoproteins E6 and E7 are ideal target …

[HTML][HTML] Native-tissue pelvic organ prolapse (POP) repair with perineorrhaphy for level III support results in reduced genital hiatus size and improved quality of life in …

AR Mothes, I Raguse, A Kather… - European Journal of …, 2023 - Elsevier
Introduction and hypothesis Recent findings address the importance of Level III defects with
increased genital hiatus being associated with pelvic organ prolapse (POP), correlated with …

Neither lymphotoxin α nor lymphotoxin β receptor expression is required for biogenesis of lymphoid aggregates or differentiation of natural killer cells in the pregnant …

A Kather, S Chantakru, H He, K Minhas, R Foster… - …, 2003 - Wiley Online Library
Gene ablation studies in mice indicate that lymphotoxin (LT) α, LTβ and LTβR are essential
for the genesis of lymph nodes (LN), normal structural development of peripheral lymphoid …

[HTML][HTML] Opportunistic salpingectomy for the primary prevention of ovarian cancer

IB Runnebaum, A Kather, J Sehouli - Deutsches Ärzteblatt …, 2022 - ncbi.nlm.nih.gov
Methods The case numbers for the main diagnoses or surgeries, performed individually or in
combination according to OPS coding, were queried from the German Federal Statistical …

Enhancement of immunogenicity of Jeg3 cells by ectopic expression of HLA‐A* 0201 and CD80

S Koc, A Kather, UR Markert, M Dürst… - American Journal of …, 2003 - Wiley Online Library
Problem: The choriocarcinoma cell line Jeg3 suppresses immunity in vitro by secretion of
soluble factors like leukemia inhibitory factor suppressing leukocyte activation. The cells lack …