Health disparities are defined as the preventable difference in the burden of disease, injury,
and violence, or opportunity to achieve optimal health that socially disadvantaged …

Hereditary endometrial carcinoma is associated with germline mutations in Lynch syndrome
genes. The role of other cancer predisposition genes is unclear. We aimed to determine the …

Objective Determine factors impacting the uptake of genetic counseling and results of
genetic testing following universal tumor testing for Lynch syndrome in patients with …

Universal testing for Lynch syndrome is now a routine component of the diagnostic work-up
of endometrial cancer patients. The purpose of this study was to identify prospectively the …

Abstract Purpose American Indian/Alaska Native (AI/AN) populations experience
significantly higher incidence and mortality rates of cervical cancer. The objective of this …

Clinical criteria, primarily young age of cancer onset and family history of signature cancers,
have been developed to identify individuals at elevated risk for Lynch syndrome with the …

Objectives Compare the incidence and mortality of gynecologic cancers among American
Indian/Alaska Native (AI/AN) women to the Non-Hispanic White (NHW) population in the …

Lynch syndrome (LS) is a hereditary cancer syndrome caused by a germline mutation in a
DNA mismatch repair gene, usually MLH1, MSH2, MSH6, or PMS2. The most common …

Background Type 2 diabetes is an increasing global health concern, most notably for
Aboriginal peoples living in Canada among whom prevalence rates are 3 to 5 times those of …

Complete genome sequences in combination with global screening methods allow parallel
analysis of multiple mutant loci to determine the requirement for specific genes in different …