[HTML][HTML] Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice
M Tsutsui, A Tanimoto, M Tamura, H Mukae… - Journal of …, 2015 - Elsevier
Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and
endothelial NOSs), all of which are expressed in almost all tissues and organs in humans …
endothelial NOSs), all of which are expressed in almost all tissues and organs in humans …
Microminipig, a non-rodent experimental animal optimized for life science research: novel atherosclerosis model induced by high fat and cholesterol diet
H Kawaguchi, N Miyoshi, N Miura, M Fujiki… - Journal of …, 2011 - Elsevier
Atherosclerotic lesions were observed in male and ovariectomized female Microminipig
(MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months …
(MMP) fed a high fat and cholesterol diet with sodium cholate (HFCD/SC) for 3 months …
[HTML][HTML] Shortened microsatellite d (CA) 21 sequence down-regulates promoter activity of matrix metalloproteinase 9 gene
S Shimajiri, N Arima, A Tanimoto, Y Murata, T Hamada… - FEBS letters, 1999 - Elsevier
One characteristic elements in the promoter of the matrix metalloproteinase 9 (MMP-9) gene
is the d (CA) repeat. To investigate whether this element regulates the transcription of the …
is the d (CA) repeat. To investigate whether this element regulates the transcription of the …
Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms
S Nakata, M Tsutsui, H Shimokawa, O Suda… - Circulation, 2008 - Am Heart Assoc
Background—The roles of nitric oxide (NO) in the cardiovascular system have been
investigated extensively in pharmacological studies with NO synthase (NOS) inhibitors and …
investigated extensively in pharmacological studies with NO synthase (NOS) inhibitors and …
Programmed cell death protein 4 down-regulates Y-box binding protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth
Programmed cell death protein 4 (PDCD4) has recently been shown to be involved in both
transcription and translation, and to regulate cell growth. However, the mechanisms …
transcription and translation, and to regulate cell growth. However, the mechanisms …
Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats
F Kamezaki, H Tasaki, K Yamashita… - American journal of …, 2008 - atsjournals.org
Rationale: Pulmonary hypertension (PH) is a life-threatening disease, characterized by
vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may …
vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may …
Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms
T Morishita, M Tsutsui, H Shimokawa… - Proceedings of the …, 2005 - National Acad Sciences
Nitric oxide (NO) is produced in almost all tissues and organs, exerting a variety of biological
actions under physiological and pathological conditions. NO is synthesized by three different …
actions under physiological and pathological conditions. NO is synthesized by three different …
Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits
S Yamada, KY Wang, A Tanimoto, J Fan… - The American journal of …, 2008 - Elsevier
Whether fatty streaks are directly followed by fibrous plaque formation in atherosclerosis
remains controversial. Disruption of the basement membrane and elastic layers is thought to …
remains controversial. Disruption of the basement membrane and elastic layers is thought to …
[HTML][HTML] Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice
M Kina-Tanada, M Sakanashi, A Tanimoto, T Kaname… - Diabetologia, 2017 - Springer
Aims/hypothesis Nitric oxide (NO) is synthesised not only from l-arginine by NO synthases
(NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are …
(NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are …
Predicted prognosis of patients with pancreatic cancer by machine learning
S Yokoyama, T Hamada, M Higashi, K Matsuo… - Clinical cancer …, 2020 - AACR
Purpose: Pancreatic cancer remains a disease of high mortality despite advanced
diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor …
diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor …