Somatic cell reprogramming-free generation of genetically modified pigs
…, S Suzuki, M Nakai, M Hashimoto, A Yasue… - Science …, 2016 - science.org
Genetically modified pigs for biomedical applications have been mainly generated using the
somatic cell nuclear transfer technique; however, this approach requires complex …
somatic cell nuclear transfer technique; however, this approach requires complex …
[HTML][HTML] Muscular atrophy of caveolin-3–deficient mice is rescued by myostatin inhibition
…, H Hagiwara, M Nakatani, A Yasue… - The Journal of …, 2006 - Am Soc Clin Investig
Caveolin-3, the muscle-specific isoform of caveolins, plays important roles in signal
transduction. Dominant-negative mutations of the caveolin-3 gene cause autosomal …
transduction. Dominant-negative mutations of the caveolin-3 gene cause autosomal …
A missense mutant myostatin causes hyperplasia without hypertrophy in the mouse muscle
M Nishi, A Yasue, S Nishimatu, T Nohno… - Biochemical and …, 2002 - Elsevier
Myostatin, which is a member of the TGF-β superfamily, is a negative regulator of skeletal
muscle formation. Double-muscled Piedmontese cattle have a C313Y mutation in myostatin …
muscle formation. Double-muscled Piedmontese cattle have a C313Y mutation in myostatin …
PERIOSTIN regulates MMP-2 expression via the αvβ3 integrin/ERK pathway in human periodontal ligament cells
T Watanabe, A Yasue, S Fujihara, E Tanaka - Archives of oral biology, 2012 - Elsevier
OBJECTIVE: During orthodontic tooth movement, activation of the vascular system in the
compressed periodontal ligament (PDL), which becomes hypoxic, is essential for …
compressed periodontal ligament (PDL), which becomes hypoxic, is essential for …
Effectiveness of house dust-mite allergen avoidance through clean room therapy in patients with atopic dermatitis
T Sanda, T Yasue, M Oohash, A Yasue - Journal of allergy and clinical …, 1992 - Elsevier
We have investigated the effectiveness of house dust-mite (HDM) allergen avoidance
through clean room (CR) therapy in patients with atopic dermatitis (AD) having high HDM …
through clean room (CR) therapy in patients with atopic dermatitis (AD) having high HDM …
[HTML][HTML] A miR-327–FGF10–FGFR2-mediated autocrine signaling mechanism controls white fat browning
…, J Zhang, M Miyake, S Oyadomari, A Yasue… - Nature …, 2017 - nature.com
Understanding the molecular mechanisms regulating beige adipocyte formation may lead to
the development of new therapies to combat obesity. Here, we report a miRNA-based …
the development of new therapies to combat obesity. Here, we report a miRNA-based …
Novel PAX9 mutations cause non-syndromic tooth agenesis
SN Mitsui, A Yasue, K Masuda… - Journal of Dental …, 2014 - journals.sagepub.com
PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth
morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In …
morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In …
Fabrications of zinc-releasing biocement combining zinc calcium phosphate to calcium phosphate cement
S Horiuchi, M Hiasa, A Yasue, K Sekine… - Journal of the …, 2014 - Elsevier
Recently, zinc-releasing bioceramics have been the focus of much attention owing to their
bone-forming ability. Thus, some types of zinc-containing calcium phosphate (eg, zinc …
bone-forming ability. Thus, some types of zinc-containing calcium phosphate (eg, zinc …
[HTML][HTML] Highly efficient targeted mutagenesis in one-cell mouse embryos mediated by the TALEN and CRISPR/Cas systems
A Yasue, SN Mitsui, T Watanabe, T Sakuma… - Scientific reports, 2014 - nature.com
Since the establishment of embryonic stem (ES) cell lines, the combined use of gene
targeting with homologous recombination has aided in elucidating the functions of various …
targeting with homologous recombination has aided in elucidating the functions of various …
[PDF][PDF] Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity
M Miyake, J Zhang, A Yasue, S Hisanaga, K Tsugawa… - Iscience, 2021 - cell.com
The eIF2α phosphorylation-dependent integrated stress response (ISR) is a signaling
pathway that maintains homeostasis in mammalian cells exposed to various stresses. Here …
pathway that maintains homeostasis in mammalian cells exposed to various stresses. Here …