Tubulin is the biochemical target for several clinically used anticancer drugs, including
paclitaxel and the vinca alkaloids vincristine and vinblastine. This review describes both the …

The vinca alkaloids have been used in the treatment of cancer for over 40 years. Their
efficacy has ensured that they remain among the drugs of choice for a number of human …

A series of substituted chalcones was synthesised and screened for cytotoxic activity against
the K562 human leukaemia cell line.(E)-3-(3 ″-Hydroxy-4 ″-methoxyphenyl)-2-methyl-1 …

The development of combretastatin as an antimitotic agent has led to an enormous effort to
design other tubulin-targeting agents. The intriguing discovery that combretastatin A-4 …

Background: Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine, and
various inhibitory agents, including specific antibodies, have been developed to block VEGF …

The α-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses
potent anticancer activity. Various chalcone analogues were synthesized and evaluated for …

The anti-tumour effects and mechanism of action of combretastatin A-4 and its prodrug,
combretastatin A-4 disodium phosphate, were examined in subcutaneous and orthotopically …

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity
study was carried out to characterise the interaction of these agents with tubulin. The …

A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin
A-4 (1) has been devised. The method uses the Perkin condensation of 3, 4, 5 …

The naturally occurring aurone 1, isolated from Uvaria hamiltonii, and a series of aurones
analogues based structurally on known tubulin binding agents were prepared and …