Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We
report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell …

Purpose: Recently, a new ABC protein, breast cancer resistance protein (BCRP), was
described. But its prognosis is not known in acute myeloid leukemia (AML). In addition, the …

Background Russell Silver syndrome (RSS) leads to prenatal and postnatal growth
retardation. About 55% of RSS patients present a loss-of-methylation of the paternal ICR1 …

Anoikis, ie apoptosis induced by detachment from the extracellular matrix, is thought to be
involved in the shedding of enterocytes at the tip of intestinal villi. Mechanisms controlling …

Abstract Purpose: P-Glycoprotein (Pgp) is associated with poor outcome in acute myeloid
leukemia (AML). We have investigated other ATP-binding cassette proteins such as BCRP …

Purpose.: Activated B-Raf alone cannot induce melanoma but must cooperate with other
signaling pathways. The phosphatidylinositol 3-kinase (PI3K)/Akt and mammalian target of …

The multidrug resistance (MDR) phenotype, induced by the overexpression of several ABC
transporters or by antiapoptotic mechanisms, has been identified as the major cause of drug …

Age‐related macular degeneration (AMD) is characterized by the formation of drusen,
extracellular deposits associated with atrophy of the retinal pigmented epithelium (RPE) …

Background The microenvironment plays a major role in the onset and progression of
metastasis. Epithelial ovarian cancer (EOC) tends to metastasize to the peritoneal cavity …

Semisynthetic homoharringtonine (ssHHT) is now being evaluated in phase II clinical trials
for the treatment of chronic myelogenous leukemia and acute myelogenous leukemia …