There is accumulating evidence that insulin has a physiological role to vasodilate skeletal
muscle vasculature in humans. This effect occurs in a dose-dependent fashion within a half …

Over the past 10 years it has become clear that intact vascular function, especially at the
level of the endothelium, is paramount in the prevention or delay of cardiovascular disease …

Challenging the view that implicit social cognition emerges from protracted social learning,
research now suggests that intergroup preferences are present at adultlike levels in early …

Background In a phase 2 trial, lenvatinib, an inhibitor of VEGF receptors 1–3, FGF receptors
1–4, PDGF receptor α, RET, and KIT, showed activity in hepatocellular carcinoma. We aimed …

Insulin resistance plays an important role in the pathophysiology of diabetes and is
associated with obesity and other cardiovascular risk factors. The “gold standard” glucose …

Background Patients with metastatic urothelial carcinoma have a dismal prognosis and few
treatment options after first-line chemotherapy. Responses to second-line treatment are …

Background Bevacizumab, a monoclonal antibody against vascular endothelial growth
factor, has shown promising preclinical and clinical activity against metastatic colorectal …

To test the hypothesis that obesity/insulin resistance impairs both endothelium-dependent
vasodilation and insulin-mediated augmentation of endothelium-dependent vasodilation, we …

OBJECTIVE—This study evaluates the ability of the incretin mimetic exenatide (exendin-4)
to improve glycemic control in patients with type 2 diabetes failing to achieve glycemic …

Purpose: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non–
small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic …