In the last two decades, isothermal titration calorimetry (ITC) has become the preferred
technique to determine the binding energetics of biological processes, including protein …

Isothermal titration calorimetry (ITC) is a powerful technique to study both protein-ligand and
protein-protein interactions. This methods chapter is devoted to describing protein-protein …

Isothermal titration calorimetry (ITC) has become the gold standard for studying molecular
interactions in solution. Although it is increasingly being used in the soft matter and synthetic …

The global health emergency generated by coronavirus disease 2019 (COVID-19) has
prompted the search for preventive and therapeutic treatments for its pathogen, the severe …

An important goal in drug development is to engineer inhibitors and ligands that have high
binding affinities for their target molecules. In optimizing these interactions, the precise …

SARS (severe acute respiratory syndrome) is caused by a newly discovered coronavirus. A
key enzyme for the maturation of this virus and, therefore, a target for drug development is …

Phenylketonuria (PKU) is an inborn error of metabolism caused by mutations in
phenylalanine hydroxylase (PAH). Over 500 disease-causing mutations have been …

The theory of the binding polynomial constitutes a very powerful formalism by which many
experimental biological systems involving ligand binding can be analyzed under a unified …

Strategies to activate abscisic acid (ABA) receptors and boost ABA signaling by small
molecules that act as ABA receptor agonists are promising biotechnological tools to …

Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic
amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native …