Colon cancer is one of the best-understood neoplasms from a genetic perspective,,, yet it
remains the second most common cause of cancer-related death, indicating that some of its …

Lynch syndrome, the most common inherited colorectal cancer syndrome in adults, is an
autosomal dominant condition caused by heterozygous germ-line mutations in DNA …

Intratumoral heterogeneity arises through the evolution of genetically diverse subclones
during tumor progression. However, it remains unknown whether cells within single genetic …

Failure of liver stiffness measurement (LSM) by transient elastography (TE, FibroScan) and
unreliable results occur in≈ 5% and 15% of patients, respectively, mainly due to obesity. In …

Background & Aims: The revised Bethesda guidelines for Lynch syndrome recommend
microsatellite instability (MSI) testing all colorectal cancers in patients diagnosed before age …

DNA replication− associated mutations are repaired by two components: polymerase
proofreading and mismatch repair. The mutation consequences of disruption to both repair …

Background Accurate tools for the noninvasive detection of hepatic steatosis are needed.
The Controlled Attenuation Parameter (CAP) specifically targets liver steatosis using a …

Importance Outcomes for patients with pancreatic ductal adenocarcinoma (PDAC) remain
poor. Advances in next-generation sequencing provide a route to therapeutic approaches …

The polo-like kinase Plk4 (also called Sak) is required for late mitotic progression, cell
survival and postgastrulation embryonic development. Here we identified a phenotype …

Background Constitutional mismatch repair deficiency (CMMRD) is a devastating cancer
predisposition syndrome for which data regarding clinical manifestations, molecular …