The urokinase plasminogen activator (uPA) and its receptor (uPAR) exert pleiotropic
functions over the course of both physiological and pathological processes. Data generated …

The mammalian immune system must specifically recognize and eliminate foreign invaders
but refrain from damaging the host. This task is accomplished in part by the production of a …

Adoptive transfer of TCR‐transgenic T cells uniformly expressing an identifiable TCR of
known peptide/MHC specificity can be used to monitor the in vivo behavior of antigen …

Although lymphoid dendritic cells (DC) are thought to play an essential role in T cell
activation, the initial physical interaction between antigen-bearing DC and antigen-specific T …

Long-living memory stem T cells (TSCM) with the ability to self-renew and the plasticity to
differentiate into potent effectors could be valuable weapons in adoptive T-cell therapy …

Proliferation of Ag-specific T cells is central to the development of protective immunity. The
concomitant stimulation of the TCR and CD28 programs resting T cells to IL-2-driven clonal …

The effects of inflammatory cytokines on naive T cells have been studied using MHC
protein/peptide complexes on microspheres, thus avoiding the use of APCs whose functions …

High mobility group box 1 (HMGB1) is an abundant chromatin protein that acts as a cytokine
when released in the extracellular milieu by necrotic and inflammatory cells. Here, we show …

Despite the wealth of information on the signals required for T cell activation in vitro, the
signals required for the generation of functional Th cells in vivo are poorly understood. We …

T cells activated by antigen receptor stimulation in the absence of accessory cell-derived
costimulatory signals lose the capacity to synthesize the growth factor interleukin-2 (IL-2), a …