User profiles for "author:A Harlé"

Alexandre Harlé

CNRS UMR 7039 CRAN, Université de Lorraine - Service de Biopathologie, ICL
Verified email at nancy.unicancer.fr
Cited by 1047

[HTML][HTML] SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma

…, A Witz, JL Merlin, P Gilson, A Harlé - International journal of …, 2020 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death
worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a …

[HTML][HTML] Deciphering tumour heterogeneity: From tissue to liquid biopsy

P Gilson, JL Merlin, A Harlé - Cancers, 2022 - mdpi.com
Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …

[HTML][HTML] Detection of microsatellite instability: state of the art and future applications in circulating tumour DNA (ctDNA)

P Gilson, JL Merlin, A Harlé - Cancers, 2021 - mdpi.com
Simple Summary Microsatellite instability (MSI) is a molecular fingerprint for defects in the
mismatch repair system (dMMR) and is associated with higher risks of cancers. MSI/dMMR …

[HTML][HTML] Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers

…, C Bonnet, J Salleron, A Leroux, JL Merlin, A Harlé - Scientific reports, 2020 - nature.com
Microsatellite instability (MSI) status is routinely assessed in patients with colorectal and
endometrial cancers as it contributes to Lynch syndrome initial screening, tumour prognosis …

A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization

…, H Diop-Ndiaye, JM Costa, J Salleron, A Harlé - Clinical Cancer …, 2021 - AACR
Purpose: Use of circulating tumor DNA (ctDNA) for diagnosis is limited regarding the low
number of target molecules in early-stage tumors. Human papillomavirus (HPV)–associated …

[HTML][HTML] Comparison of pathogenicity prediction tools on somatic variants

V Suybeng, F Koeppel, A Harlé, E Rouleau - The Journal of Molecular …, 2020 - Elsevier
Genomic sequencing is increasingly used in managing patients with cancer. Interpretation of
somatic variants and their pathogenicity is often complex. Pathogenicity prediction tools are …

[HTML][HTML] Emerging roles of DDB2 in cancer

…, A Witz, JL Merlin, P Becuwe, A Harlé - International Journal of …, 2019 - mdpi.com
Damage-specific DNA-binding protein 2 (DDB2) was originally identified as a DNA damage
recognition factor that facilitates global genomic nucleotide excision repair (GG-NER) in …

[HTML][HTML] Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples

A Harlé, J Guillet, J Thomas, X Sastre-Garau… - Scientific Reports, 2018 - nature.com
Specific HPV genotypes have been recognized as risk factors inducing head and neck
cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect …

Technical considerations for circulating tumor DNA detection in oncology

…, P Gilson, JL Merlin, L Au, A Harlé - Expert review of …, 2019 - Taylor & Francis
Introduction: Blood draw or collection of other body fluids, known as 'liquid biopsies' are
generally less invasive procedures than tumor biopsies. Cell-free tumor DNA (ctDNA) is …

[HTML][HTML] Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification …

A Harlé, J Salleron, C Franczak, C Dubois… - PLoS …, 2016 - journals.plos.org
Background Metastatic melanoma is a severe disease with one of the highest mortality rate
in skin diseases. Overall survival has significantly improved with immunotherapy and …