User profiles for "author:A Harlé"
Alexandre HarléCNRS UMR 7039 CRAN, Université de Lorraine - Service de Biopathologie, ICL Verified email at nancy.unicancer.fr Cited by 1047 |
[HTML][HTML] SMAD4 and the TGFβ pathway in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death
worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a …
worldwide. PDAC is an aggressive disease with an 11-month median overall survival and a …
[HTML][HTML] Deciphering tumour heterogeneity: From tissue to liquid biopsy
Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
[HTML][HTML] Detection of microsatellite instability: state of the art and future applications in circulating tumour DNA (ctDNA)
Simple Summary Microsatellite instability (MSI) is a molecular fingerprint for defects in the
mismatch repair system (dMMR) and is associated with higher risks of cancers. MSI/dMMR …
mismatch repair system (dMMR) and is associated with higher risks of cancers. MSI/dMMR …
[HTML][HTML] Evaluation of 3 molecular-based assays for microsatellite instability detection in formalin-fixed tissues of patients with endometrial and colorectal cancers
Microsatellite instability (MSI) status is routinely assessed in patients with colorectal and
endometrial cancers as it contributes to Lynch syndrome initial screening, tumour prognosis …
endometrial cancers as it contributes to Lynch syndrome initial screening, tumour prognosis …
A NGS-based blood test for the diagnosis of invasive HPV-associated carcinomas with extensive viral genomic characterization
…, H Diop-Ndiaye, JM Costa, J Salleron, A Harlé - Clinical Cancer …, 2021 - AACR
Purpose: Use of circulating tumor DNA (ctDNA) for diagnosis is limited regarding the low
number of target molecules in early-stage tumors. Human papillomavirus (HPV)–associated …
number of target molecules in early-stage tumors. Human papillomavirus (HPV)–associated …
[HTML][HTML] Comparison of pathogenicity prediction tools on somatic variants
V Suybeng, F Koeppel, A Harlé, E Rouleau - The Journal of Molecular …, 2020 - Elsevier
Genomic sequencing is increasingly used in managing patients with cancer. Interpretation of
somatic variants and their pathogenicity is often complex. Pathogenicity prediction tools are …
somatic variants and their pathogenicity is often complex. Pathogenicity prediction tools are …
[HTML][HTML] Emerging roles of DDB2 in cancer
Damage-specific DNA-binding protein 2 (DDB2) was originally identified as a DNA damage
recognition factor that facilitates global genomic nucleotide excision repair (GG-NER) in …
recognition factor that facilitates global genomic nucleotide excision repair (GG-NER) in …
[HTML][HTML] Evaluation and validation of HPV real-time PCR assay for the detection of HPV DNA in oral cytobrush and FFPE samples
A Harlé, J Guillet, J Thomas, X Sastre-Garau… - Scientific Reports, 2018 - nature.com
Specific HPV genotypes have been recognized as risk factors inducing head and neck
cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect …
cancers (HNC). The aim of this study was to validate a real-time PCR assay to detect …
Technical considerations for circulating tumor DNA detection in oncology
Introduction: Blood draw or collection of other body fluids, known as 'liquid biopsies' are
generally less invasive procedures than tumor biopsies. Cell-free tumor DNA (ctDNA) is …
generally less invasive procedures than tumor biopsies. Cell-free tumor DNA (ctDNA) is …
[HTML][HTML] Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification …
A Harlé, J Salleron, C Franczak, C Dubois… - PLoS …, 2016 - journals.plos.org
Background Metastatic melanoma is a severe disease with one of the highest mortality rate
in skin diseases. Overall survival has significantly improved with immunotherapy and …
in skin diseases. Overall survival has significantly improved with immunotherapy and …