[HTML][HTML] Targeting tumor microenvironment for cancer therapy
C Roma-Rodrigues, R Mendes, PV Baptista… - International journal of …, 2019 - mdpi.com
Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system
AP Fernandes, A Holmgren - Antioxidants and Redox Signaling, 2004 - liebertpub.com
Most cells contain high levels of glutathione and multiple glutaredoxins, which utilize the
reducing power of glutathione to catalyze disulfide reductions in the presence of NADPH …
reducing power of glutathione to catalyze disulfide reductions in the presence of NADPH …
[HTML][HTML] Nano-strategies to fight multidrug resistant bacteria—“A Battle of the Titans”
PV Baptista, MP McCusker, A Carvalho… - Frontiers in …, 2018 - frontiersin.org
Infectious diseases remain one of the leading causes of morbidity and mortality worldwide.
The WHO and CDC have expressed serious concern regarding the continued increase in …
The WHO and CDC have expressed serious concern regarding the continued increase in …
Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis
Importance Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …
for COVID-19 have variously reported benefit, no effect, and harm. Objective To estimate the …
[HTML][HTML] Efficacy of tocilizumab in patients hospitalized with Covid-19
JH Stone, MJ Frigault, NJ Serling-Boyd… - … England Journal of …, 2020 - Mass Medical Soc
Background The efficacy of interleukin-6 receptor blockade in hospitalized patients with
coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is …
coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is …
[HTML][HTML] Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to …
Background Many causes of vision impairment can be prevented or treated. With an ageing
global population, the demands for eye health services are increasing. We estimated the …
global population, the demands for eye health services are increasing. We estimated the …
[HTML][HTML] Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label …
RD Lopes, RHM Furtado, AVS Macedo, B Bronhara… - The Lancet, 2021 - thelancet.com
Background COVID-19 is associated with a prothrombotic state leading to adverse clinical
outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised …
outcomes. Whether therapeutic anticoagulation improves outcomes in patients hospitalised …
[HTML][HTML] Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study
Background To contribute to the WHO initiative, VISION 2020: The Right to Sight, an
assessment of global vision impairment in 2020 and temporal change is needed. We aimed …
assessment of global vision impairment in 2020 and temporal change is needed. We aimed …
Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial
Importance The efficacy of vitamin D 3 supplementation in coronavirus disease 2019
(COVID-19) remains unclear. Objective To investigate the effect of a single high dose of …
(COVID-19) remains unclear. Objective To investigate the effect of a single high dose of …
Anthropometrical parameters and markers of obesity in rats
ELB Novelli, YS Diniz, CM Galhardi… - Laboratory …, 2007 - journals.sagepub.com
The present study was undertaken to determine anthropometrical parameters in male adult
Wistar rats. We tested the hypothesis that the anthropometrical index may identify obesity …
Wistar rats. We tested the hypothesis that the anthropometrical index may identify obesity …