Oncogenic PI3K deregulates transcription and translation
There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer
pathogenesis. Experimental data document a requirement for deregulation of both …
pathogenesis. Experimental data document a requirement for deregulation of both …
Coordination chemistry and catalysis with hemilabile oxygen-phosphorus ligands
A Bader, E Lindner - Coordination chemistry reviews, 1991 - Elsevier
Classification of 0, P ligands................(i) Ether-phosphines and furylphosphines........(ii) p-
Ketophosphines(phosphinoenolates) and a-ketoylids (iii) Phosphinocarboxylates …
Ketophosphines(phosphinoenolates) and a-ketoylids (iii) Phosphinocarboxylates …
[HTML][HTML] miR-34–a microRNA replacement therapy is headed to the clinic
AG Bader - Frontiers in genetics, 2012 - frontiersin.org
MicroRNA-34 (miR-34) is a master regulator of tumor suppression. It is downregulated in
numerous cancers and inhibits malignant growth by repressing genes involved in various …
numerous cancers and inhibits malignant growth by repressing genes involved in various …
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
C Liu, K Kelnar, B Liu, X Chen, T Calhoun-Davis, H Li… - Nature medicine, 2011 - nature.com
Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and
metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs,,,, and …
metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs,,,, and …
[HTML][HTML] Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …
Size-and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates
The efficacy of implanted biomedical devices is often compromised by host recognition and
subsequent foreign body responses. Here, we demonstrate the role of the geometry of …
subsequent foreign body responses. Here, we demonstrate the role of the geometry of …
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
S Kang, AG Bader, PK Vogt - Proceedings of the National …, 2005 - National Acad Sciences
Mutations in genes that encode components of the phosphatidyl-inositol 3-kinase (PI3-
kinase) signaling pathway are common in human cancer. The recent discovery of …
kinase) signaling pathway are common in human cancer. The recent discovery of …
The let-7 microRNA reduces tumor growth in mouse models of lung cancer
A Esquela-Kerscher, P Trang, JF Wiggins, L Patrawala… - Cell cycle, 2008 - Taylor & Francis
MicroRNAs have been increasingly implicated in human cancer and interest has grown
about the potential to use microRNAs to combat cancer. Lung cancer is the most prevalent …
about the potential to use microRNAs to combat cancer. Lung cancer is the most prevalent …
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dysfunctional endothelium contributes to more diseases than any other tissue in the body.
Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in …
Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in …
Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors
MS Beg, AJ Brenner, J Sachdev, M Borad… - Investigational new …, 2017 - Springer
Purpose Naturally occurring tumor suppressor microRNA-34a (miR-34a) downregulates the
expression of> 30 oncogenes across multiple oncogenic pathways, as well as genes …
expression of> 30 oncogenes across multiple oncogenic pathways, as well as genes …