Implications regarding atypical squamous cells of undetermined significance among women residing in a US-Mexico border city

Int J Gynecol Cancer. 2006 May-Jun;16(3):1014-6. doi: 10.1111/j.1525-1438.2006.00597.x.

Abstract

We conducted a study of Mexican American women living in a US-Mexico border city who attended a gynecology clinic for Papanicolaou (Pap) smear. The objective of this study was to describe the cytologic outcomes of women who had atypical squamous cells of undetermined significance (ASCUS) diagnosis after a Pap smear and to observe any changes during follow-up colposcopy. A total of 852 abnormal Pap smear were identified through a computer search for a 6-month period. Histology data were available for 317 cases. Benign findings were observed in 45.4% of cervical biopsies. A clinically significant diagnosis was reported in the remaining tissue sample. The diagnosis report was either single or combined and recorded as follows: human papilloma virus 46.3%, cervical intraepithelial neoplasia (CIN) 1, 23.6%; CIN 2, 5.6%; and CIN 3, 1.5%. There was one case of invasive cervical cancer. Overall, the incidence rate of ASCUS was 5%. However, we found that a significant proportion of this population had CIN 1 through CIN 3. Furthermore, this population has traditionally been noncompliant and routinely failed to attend follow-up appointments. Based on these results, the clinician should not ignore an initial abnormal Pap smear. Therefore, it is not unreasonable to perform colposcopy in Mexican American patients with a first time diagnosis of ASCUS on routine Pap smear.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Colposcopy / methods
  • DNA Probes, HPV / analysis
  • Female
  • Humans
  • Mass Screening / methods
  • Mexican Americans
  • Mexico / epidemiology
  • Middle Aged
  • Papanicolaou Test
  • Precancerous Conditions / diagnosis*
  • Precancerous Conditions / epidemiology*
  • United States / epidemiology
  • Uterine Cervical Dysplasia / diagnosis*
  • Uterine Cervical Dysplasia / epidemiology
  • Uterine Cervical Neoplasms / diagnosis*
  • Uterine Cervical Neoplasms / epidemiology
  • Vaginal Smears / statistics & numerical data

Substances

  • DNA Probes, HPV